Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy.

Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy.

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a small conductance chloride ion channel that may interact directly with other channels including the epithelial sodium channel (ENaC). CFTR is known to be more abundant in the airway epithelium during the second trimester of...

Full description

Bibliographic Details
Main Authors:	Broackes-Carter, F, Mouchel, N, Gill, D, Hyde, S, Bassett, J, Harris, A
Format:	Journal article
Language:	English
Published:	2002

Similar Items

DEVELOPMENT, PRODUCTION AND EVALUATION OF CLINICAL GRADE CFTR EXPRESSION PLASMID FOR CF LUNG GENE THERAPY
by: Gill, DR, et al.
Published: (2010)

Ovine male genital duct epithelial cells differentiate in vitro and express functional CFTR and ENaC
by: Bertog, M, et al.
Published: (2000)

Ovine male genital duct epithelial cells differentiate in vitro and express functional CFTR and ENaC.
by: Bertog, M, et al.
Published: (2000)

SAFETY AND EXPRESSION OF A SINGLE DOSE OF LIPID-MEDIATED CFTR GENE THERAPY TO THE UPPER AND LOWER AIRWAYS OF PATIENTS WITH CF
by: Davies, J, et al.
Published: (2011)

Comparative effects of CFTR modulators on phagocytic, metabolic and inflammatory profiles of CF and nonCF macrophages
by: Daniel S. Aridgides, et al.
Published: (2023-07-01)

Optimizing aerosol gene delivery and expression in the ovine lung.
by: McLachlan, G, et al.
Published: (2007)

Adenovirus-mediated in utero expression of CFTR does not improve survival of CFTR knockout mice.
by: Davies, L, et al.
Published: (2008)

Self-reactive CFTR T cells in humans: implications for gene therapy.
by: Calcedo, R, et al.
Published: (2013)

Delivery of genes into the CF airway
by: Gill, D, et al.
Published: (2014)

Non-viral CFTR gene delivery to the lungs of Cystic Fibrosis patients
by: Hyde, S
Published: (2013)

Fertility, Pregnancy and Lactation Considerations for Women with CF in the CFTR Modulator Era
by: Raksha Jain, et al.
Published: (2021-05-01)

Extensive <i>CFTR</i> Gene Analysis Revealed a Higher Occurrence of Cystic Fibrosis Transmembrane Regulator-Related Disorders (CFTR-RD) among CF Carriers
by: Maria Valeria Esposito, et al.
Published: (2020-11-01)

Interaction of intestinal and pancreatic transcription factors in the regulation of CFTR gene expression.
by: McCarthy, V, et al.
Published: (2009)

EVALUATION OF SAFETY AND GENE EXPRESSION WITH A SINGLE DOSE OF PGM169/GL67A ADMINISTERED TO THE NOSE AND LUNG OF INDIVIDUALS WITH CF: THE UK CF GENE THERAPY CONSORTIUM "PILOT STUDY"
by: Davies, J, et al.
Published: (2009)

Development of an immunocytochemical assay to detect human CFTR expression following gene therapy
by: Davidson, H, et al.
Published: (2008)

CFTR Modulator Therapy for Rare CFTR Mutants
by: Marco Mergiotti, et al.
Published: (2022-04-01)

Tissue-Specific Regulation of <i>CFTR</i> Gene Expression
by: Clara Blotas, et al.
Published: (2023-06-01)

Longevity of expression and levels of expression of gene therapy vectors using ovine air-liquid interface tracheal cells
by: Davidson, H, et al.
Published: (2007)

SAFETY AND EXPRESSION OF A SINGLE DOSE OF LIPID-MEDIATED CFTR GENE THERAPY TO THE UPPER AND LOWER AIRWAYS OF PATIENTS WITH CYSTIC FIBROSIS
by: Davies, G, et al.
Published: (2011)

Cumulative CFTR expression following repeated aerosol delivery of non-viral pGM169/GL67A formulation to mouse lung
by: Alton, E, et al.
Published: (2012)

The gut-lung axis in the CFTR modulator era
by: Florian Lussac-Sorton, et al.
Published: (2023-09-01)

An immunocytochemical assay to detect human CFTR expression following gene transfer.
by: Davidson, H, et al.
Published: (2009)

Lessons learned from lung and liver in-vivo gene therapy: implications for the future
by: van Haasteren, J, et al.
Published: (2018)

Assessment of CFTR function after gene transfer in vitro and in vivo.
by: Griesenbach, U, et al.
Published: (2008)

SPATIALLY AND TEMPORALLY RESOLVED LASER-INDUCED FLUORESCENCE MEASUREMENTS OF CF2 AND CF RADICALS IN A CF4 RF PLASMA
by: Booth, J, et al.
Published: (1989)

Features of CFTR mRNA and implications for therapeutics development
by: JaNise J. Jackson, et al.
Published: (2023-04-01)

Prediction of Real-World Long-Term Outcomes of People with CF Homozygous for the F508del Mutation Treated with CFTR Modulators
by: Danya Muilwijk, et al.
Published: (2021-12-01)

The Cystic Fibrosis Transmembrane Regulator (CFTR) in the kidney
by: MARCELO M. MORALES, et al.
Published: (2000-09-01)

EVALUATION OF SAFETY AND GENE EXPRESSION WITH A SINGLE DOSE OF PGM169/GL67A ADMINISTERED TO THE NOSE AND LUNG OF INDIVIDUALS WITH CYSTIC FIBROSIS: THE UK CF GENE THERAPY CONSORTIUM "PILOT STUDY''
by: Davies, J, et al.
Published: (2009)

Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity.
by: Holder, E, et al.
Published: (2010)

Regulation of porcine and ovine stearoyl co-enzyme a desaturase gene expression /
by: Razauden M. Zulkifli
Published: (2007)

Genetic medicines for CF: Hype versus reality
by: Alton, E, et al.
Published: (2016)

OPTIMISATION OF MOLECULAR ASSAYS FOR CLINICAL TRIAL OF GL67A/PDNA DELIVERY TO NOSE AND LUNG OF CF PATIENTS
by: Sumner-Jones, S, et al.
Published: (2009)

The effect of CFTR modulators on structural lung disease in cystic fibrosis
by: L. Clara Mok, et al.
Published: (2023-04-01)

Update on the UK CF Gene Therapy Consortium Multidoes, non-viral, gene therapy trial
by: Alton, E, et al.
Published: (2012)

EXERCISE CAPACITY AND PHYSICAL ACTIVITY IN PATIENTS WITH CF: DATA FROM THE UK CF GENE THERAPY CONSORTIUM (UKCFGTC) 'RUN-IN' STUDY
by: Saunders, C, et al.
Published: (2010)

Stochastic tracking of infection in a CF lung.
by: Sara Zarei, et al.
Published: (2014-01-01)

Pharmacological Responses of the G542X-CFTR to CFTR Modulators
by: Xinxiu Fang, et al.
Published: (2022-06-01)

Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid-DNA complexes to ovine lung segments.
by: Emerson, M, et al.
Published: (2003)

UPDATE ON THE UK CF GENE THERAPY CONSORTIUM MULTIDOSE, NON-VIRAL, GENE THERAPY TRIAL
by: Alton, E, et al.
Published: (2012)