The effect of beta 2-adrenoceptor stimulation and blockade of L-type calcium channels on in vivo Na+/H+ antiporter activity in rat skeletal muscle.
We have studied the in vivo response of the Na+/H+ antiporter in skeletal muscle to beta 2-adrenoceptor stimulation with isoprenaline and the effect of blocking L-type calcium channels with nifedipine. Na+/H+ antiporter activity in skeletal muscle in vivo increased after beta 2-adrenoceptor stimulat...
| Main Authors: | , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
1991
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| _version_ | 1826292865319305216 |
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| author | Syme, P Brunotte, F Green, Y Aronson, J Radda, G |
| author_facet | Syme, P Brunotte, F Green, Y Aronson, J Radda, G |
| author_sort | Syme, P |
| collection | OXFORD |
| description | We have studied the in vivo response of the Na+/H+ antiporter in skeletal muscle to beta 2-adrenoceptor stimulation with isoprenaline and the effect of blocking L-type calcium channels with nifedipine. Na+/H+ antiporter activity in skeletal muscle in vivo increased after beta 2-adrenoceptor stimulation with isoprenaline; nifedipine attenuated that effect. This suggests that opening of L-type calcium channels is necessary for full activation of the Na+/H+ antiporter in skeletal muscle. Bleeding also increased Na/H+ antiporter activity, which we believe could be explained by an increase in sympathetic nervous system activity as a result of hypotension. This may be one of the mechanisms by which animals under stress prepare their skeletal muscle for exercise as part of the 'fright and flight' reaction. |
| first_indexed | 2024-03-07T03:21:16Z |
| format | Journal article |
| id | oxford-uuid:b785306b-c3b8-4f70-bfc8-e6ac6c6cc6e0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:21:16Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:b785306b-c3b8-4f70-bfc8-e6ac6c6cc6e02022-03-27T04:49:12ZThe effect of beta 2-adrenoceptor stimulation and blockade of L-type calcium channels on in vivo Na+/H+ antiporter activity in rat skeletal muscle.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b785306b-c3b8-4f70-bfc8-e6ac6c6cc6e0EnglishSymplectic Elements at Oxford1991Syme, PBrunotte, FGreen, YAronson, JRadda, GWe have studied the in vivo response of the Na+/H+ antiporter in skeletal muscle to beta 2-adrenoceptor stimulation with isoprenaline and the effect of blocking L-type calcium channels with nifedipine. Na+/H+ antiporter activity in skeletal muscle in vivo increased after beta 2-adrenoceptor stimulation with isoprenaline; nifedipine attenuated that effect. This suggests that opening of L-type calcium channels is necessary for full activation of the Na+/H+ antiporter in skeletal muscle. Bleeding also increased Na/H+ antiporter activity, which we believe could be explained by an increase in sympathetic nervous system activity as a result of hypotension. This may be one of the mechanisms by which animals under stress prepare their skeletal muscle for exercise as part of the 'fright and flight' reaction. |
| spellingShingle | Syme, P Brunotte, F Green, Y Aronson, J Radda, G The effect of beta 2-adrenoceptor stimulation and blockade of L-type calcium channels on in vivo Na+/H+ antiporter activity in rat skeletal muscle. |
| title | The effect of beta 2-adrenoceptor stimulation and blockade of L-type calcium channels on in vivo Na+/H+ antiporter activity in rat skeletal muscle. |
| title_full | The effect of beta 2-adrenoceptor stimulation and blockade of L-type calcium channels on in vivo Na+/H+ antiporter activity in rat skeletal muscle. |
| title_fullStr | The effect of beta 2-adrenoceptor stimulation and blockade of L-type calcium channels on in vivo Na+/H+ antiporter activity in rat skeletal muscle. |
| title_full_unstemmed | The effect of beta 2-adrenoceptor stimulation and blockade of L-type calcium channels on in vivo Na+/H+ antiporter activity in rat skeletal muscle. |
| title_short | The effect of beta 2-adrenoceptor stimulation and blockade of L-type calcium channels on in vivo Na+/H+ antiporter activity in rat skeletal muscle. |
| title_sort | effect of beta 2 adrenoceptor stimulation and blockade of l type calcium channels on in vivo na h antiporter activity in rat skeletal muscle |
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