White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy.
This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 mild cognitive impairment (MCI), and 154 AD subjects with seri...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2016
|
| _version_ | 1826292870086131712 |
|---|---|
| author | Fiford, C Manning, E Bartlett, J Cash, D Malone, I Ridgway, G Lehmann, M Leung, K Sudre, C Ourselin, S Biessels, G Carmichael, O Fox, N Cardoso, M Barnes, J |
| author_facet | Fiford, C Manning, E Bartlett, J Cash, D Malone, I Ridgway, G Lehmann, M Leung, K Sudre, C Ourselin, S Biessels, G Carmichael, O Fox, N Cardoso, M Barnes, J |
| author_sort | Fiford, C |
| collection | OXFORD |
| description | This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 mild cognitive impairment (MCI), and 154 AD subjects with serial volumetric 1.5-T MRI. CSF Aβ42 and total tau were measured (n = 353). Brain and hippocampal loss were quantified from serial MRI using the boundary shift integral (BSI). Multiple linear regression models assessed the relationships between WMHs and hippocampal and brain atrophy rates. Models were refitted adjusting for (a) concurrent brain/hippocampal atrophy rates and (b) CSF Aβ42 and tau in subjects with CSF data. WMH burden was positively associated with hippocampal atrophy rate in controls (P = 0.002) and MCI subjects (P = 0.03), and with brain atrophy rate in controls (P = 0.03). The associations with hippocampal atrophy rate remained following adjustment for concurrent brain atrophy rate in controls and MCIs, and for CSF biomarkers in controls (P = 0.007). These novel results suggest that vascular damage alongside AD pathology is associated with disproportionately greater hippocampal atrophy in nondemented older adults. |
| first_indexed | 2024-03-07T03:21:21Z |
| format | Journal article |
| id | oxford-uuid:b78c0bd4-bee9-4014-80e2-284095fa7d7d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:21:21Z |
| publishDate | 2016 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:b78c0bd4-bee9-4014-80e2-284095fa7d7d2022-03-27T04:49:28ZWhite matter hyperintensities are associated with disproportionate progressive hippocampal atrophy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b78c0bd4-bee9-4014-80e2-284095fa7d7dEnglishSymplectic Elements at OxfordWiley2016Fiford, CManning, EBartlett, JCash, DMalone, IRidgway, GLehmann, MLeung, KSudre, COurselin, SBiessels, GCarmichael, OFox, NCardoso, MBarnes, JThis study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 mild cognitive impairment (MCI), and 154 AD subjects with serial volumetric 1.5-T MRI. CSF Aβ42 and total tau were measured (n = 353). Brain and hippocampal loss were quantified from serial MRI using the boundary shift integral (BSI). Multiple linear regression models assessed the relationships between WMHs and hippocampal and brain atrophy rates. Models were refitted adjusting for (a) concurrent brain/hippocampal atrophy rates and (b) CSF Aβ42 and tau in subjects with CSF data. WMH burden was positively associated with hippocampal atrophy rate in controls (P = 0.002) and MCI subjects (P = 0.03), and with brain atrophy rate in controls (P = 0.03). The associations with hippocampal atrophy rate remained following adjustment for concurrent brain atrophy rate in controls and MCIs, and for CSF biomarkers in controls (P = 0.007). These novel results suggest that vascular damage alongside AD pathology is associated with disproportionately greater hippocampal atrophy in nondemented older adults. |
| spellingShingle | Fiford, C Manning, E Bartlett, J Cash, D Malone, I Ridgway, G Lehmann, M Leung, K Sudre, C Ourselin, S Biessels, G Carmichael, O Fox, N Cardoso, M Barnes, J White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy. |
| title | White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy. |
| title_full | White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy. |
| title_fullStr | White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy. |
| title_full_unstemmed | White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy. |
| title_short | White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy. |
| title_sort | white matter hyperintensities are associated with disproportionate progressive hippocampal atrophy |
| work_keys_str_mv | AT fifordc whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT manninge whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT bartlettj whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT cashd whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT malonei whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT ridgwayg whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT lehmannm whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT leungk whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT sudrec whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT ourselins whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT biesselsg whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT carmichaelo whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT foxn whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT cardosom whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy AT barnesj whitematterhyperintensitiesareassociatedwithdisproportionateprogressivehippocampalatrophy |