Resting functional connectivity reveals residual functional activity in Alzheimer's disease
Background Functional magnetic resonance imaging (fMRI) has great potential for measuring mechanisms of functional changes in Alzheimer's disease (AD) and mild cognitive impairment, but task fMRI studies have produced conflicting results, partly due to failure to account for underlying morpholo...
| Auteurs principaux: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Langue: | English |
| Publié: |
2013
|
| _version_ | 1826292879181479936 |
|---|---|
| author | Zamboni, G Wilcock, G Douaud, G Drazich, E McCulloch, E Filippini, N Tracey, I Brooks, J Smith, S Jenkinson, M Mackay, C |
| author_facet | Zamboni, G Wilcock, G Douaud, G Drazich, E McCulloch, E Filippini, N Tracey, I Brooks, J Smith, S Jenkinson, M Mackay, C |
| author_sort | Zamboni, G |
| collection | OXFORD |
| description | Background Functional magnetic resonance imaging (fMRI) has great potential for measuring mechanisms of functional changes in Alzheimer's disease (AD) and mild cognitive impairment, but task fMRI studies have produced conflicting results, partly due to failure to account for underlying morphological changes and to variations in patients' ability to perform the tasks. Resting fMRI has potential for assessing brain function independently from a task, but greater understanding of how networks of resting functional connectivity relate to the functioning of the brain is needed. We combined resting fMRI and task fMRI to examine the correspondence between these methods in individuals with cognitive impairment. Methods Eighty elderly (25 control subjects, 25 mild cognitive impairment, 30 AD) underwent a combined multimodal magnetic resonance imaging protocol including task fMRI and resting fMRI. Task fMRI data were acquired during the execution of a memory paradigm designed to account for differences in task performance. Structural and physiological confounds were modeled for both fMRI modalities. Results Successful recognition was associated with increased task fMRI activation in lateral prefrontal regions in AD relative to control subjects; this overlapped with increased resting fMRI functional connectivity in the same regions. Conclusions Our results show that task fMRI and resting fMRI are sensitive markers of residual ability over the known changes in brain morphology and cognition occurring in AD and suggest that resting fMRI has a potential to measure the effect of new treatments. © 2013 Society of Biological Psychiatry. |
| first_indexed | 2024-03-07T03:21:30Z |
| format | Journal article |
| id | oxford-uuid:b7965ae6-6026-496f-a993-0d3a98ad6efc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:21:30Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:b7965ae6-6026-496f-a993-0d3a98ad6efc2022-03-27T04:49:48ZResting functional connectivity reveals residual functional activity in Alzheimer's diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b7965ae6-6026-496f-a993-0d3a98ad6efcEnglishSymplectic Elements at Oxford2013Zamboni, GWilcock, GDouaud, GDrazich, EMcCulloch, EFilippini, NTracey, IBrooks, JSmith, SJenkinson, MMackay, CBackground Functional magnetic resonance imaging (fMRI) has great potential for measuring mechanisms of functional changes in Alzheimer's disease (AD) and mild cognitive impairment, but task fMRI studies have produced conflicting results, partly due to failure to account for underlying morphological changes and to variations in patients' ability to perform the tasks. Resting fMRI has potential for assessing brain function independently from a task, but greater understanding of how networks of resting functional connectivity relate to the functioning of the brain is needed. We combined resting fMRI and task fMRI to examine the correspondence between these methods in individuals with cognitive impairment. Methods Eighty elderly (25 control subjects, 25 mild cognitive impairment, 30 AD) underwent a combined multimodal magnetic resonance imaging protocol including task fMRI and resting fMRI. Task fMRI data were acquired during the execution of a memory paradigm designed to account for differences in task performance. Structural and physiological confounds were modeled for both fMRI modalities. Results Successful recognition was associated with increased task fMRI activation in lateral prefrontal regions in AD relative to control subjects; this overlapped with increased resting fMRI functional connectivity in the same regions. Conclusions Our results show that task fMRI and resting fMRI are sensitive markers of residual ability over the known changes in brain morphology and cognition occurring in AD and suggest that resting fMRI has a potential to measure the effect of new treatments. © 2013 Society of Biological Psychiatry. |
| spellingShingle | Zamboni, G Wilcock, G Douaud, G Drazich, E McCulloch, E Filippini, N Tracey, I Brooks, J Smith, S Jenkinson, M Mackay, C Resting functional connectivity reveals residual functional activity in Alzheimer's disease |
| title | Resting functional connectivity reveals residual functional activity in Alzheimer's disease |
| title_full | Resting functional connectivity reveals residual functional activity in Alzheimer's disease |
| title_fullStr | Resting functional connectivity reveals residual functional activity in Alzheimer's disease |
| title_full_unstemmed | Resting functional connectivity reveals residual functional activity in Alzheimer's disease |
| title_short | Resting functional connectivity reveals residual functional activity in Alzheimer's disease |
| title_sort | resting functional connectivity reveals residual functional activity in alzheimer s disease |
| work_keys_str_mv | AT zambonig restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT wilcockg restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT douaudg restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT draziche restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT mcculloche restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT filippinin restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT traceyi restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT brooksj restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT smiths restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT jenkinsonm restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease AT mackayc restingfunctionalconnectivityrevealsresidualfunctionalactivityinalzheimersdisease |