Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard

Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard

Recent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may n...

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Bibliographic Details
Main Authors: Sanderson, A, Beverley, P
Format: Journal article
Language:English
Published: 1983
Description
Summary:Recent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may not respond in this way. As a result, they may lack the antigens that would make them vulnerable to immune mechanisms dependent on T cells which recognize class-I self-MHC antigens. © 1983.

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