Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard
Recent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may n...
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
1983
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| Shrnutí: | Recent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may not respond in this way. As a result, they may lack the antigens that would make them vulnerable to immune mechanisms dependent on T cells which recognize class-I self-MHC antigens. © 1983. |
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