Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard
Recent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may n...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1983
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| _version_ | 1826292904233009152 |
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| author | Sanderson, A Beverley, P |
| author_facet | Sanderson, A Beverley, P |
| author_sort | Sanderson, A |
| collection | OXFORD |
| description | Recent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may not respond in this way. As a result, they may lack the antigens that would make them vulnerable to immune mechanisms dependent on T cells which recognize class-I self-MHC antigens. © 1983. |
| first_indexed | 2024-03-07T03:21:53Z |
| format | Journal article |
| id | oxford-uuid:b7b33358-ccb7-43f5-845b-aa977381a2cc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:21:53Z |
| publishDate | 1983 |
| record_format | dspace |
| spelling | oxford-uuid:b7b33358-ccb7-43f5-845b-aa977381a2cc2022-03-27T04:50:31ZInterferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head YardJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b7b33358-ccb7-43f5-845b-aa977381a2ccEnglishSymplectic Elements at Oxford1983Sanderson, ABeverley, PRecent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may not respond in this way. As a result, they may lack the antigens that would make them vulnerable to immune mechanisms dependent on T cells which recognize class-I self-MHC antigens. © 1983. |
| spellingShingle | Sanderson, A Beverley, P Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard |
| title | Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard |
| title_full | Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard |
| title_fullStr | Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard |
| title_full_unstemmed | Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard |
| title_short | Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy. A blinkered view from Nag's Head Yard |
| title_sort | interferon β 2 microglobulin and immunoselection in the pathway to malignancy a blinkered view from nag s head yard |
| work_keys_str_mv | AT sandersona interferonb2microglobulinandimmunoselectioninthepathwaytomalignancyablinkeredviewfromnagsheadyard AT beverleyp interferonb2microglobulinandimmunoselectioninthepathwaytomalignancyablinkeredviewfromnagsheadyard |