The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.

OBJECTIVE: In mice, haploinsufficiency of the IGF-1 receptor (IGF-1R(+/-)), at a whole-body level, increases resistance to inflammation and oxidative stress, but the underlying mechanisms are unclear. We hypothesized that by forming insulin-resistant heterodimers composed of one IGF-1Rαβ and one ins...

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Main Authors:	Abbas, A, Imrie, H, Viswambharan, H, Sukumar, P, Rajwani, A, Cubbon, R, Gage, M, Smith, J, Galloway, S, Yuldeshava, N, Kahn, M, Xuan, S, Grant, P, Channon, K, Beech, D, Wheatcroft, S, Kearney, M
Format:	Journal article
Language:	English
Published:	2011

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium by Abbas, A, Imrie, H, Viswambharan, H, Sukumar, P, Rajwani, A, Cubbon, R, Gage, M, Smith, J, Galloway, S, Yuldeshava, N, Kahn, M, Xuan, S, Grant, P, Channon, K, Beech, D, Wheatcroft, S, Kearney, M

Published 2011

Journal article

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.

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