A nonparametric significance test for sampled networks
<h4>Motivation</h4> <p>Our work is motivated by an interest in constructing a protein-protein interaction network that captures key features associated with Parkinson’s disease. While there is an abundance of subnetwork construction methods available, it is often far from obvious...
| Hoofdauteurs: | , , , , |
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| Formaat: | Journal article |
| Gepubliceerd in: |
Oxford University Press
2017
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| _version_ | 1826292924656123904 |
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| author | Elliott, A Leicht, E Whitmore, A Reinert, G Reed-Tsochas, F |
| author_facet | Elliott, A Leicht, E Whitmore, A Reinert, G Reed-Tsochas, F |
| author_sort | Elliott, A |
| collection | OXFORD |
| description | <h4>Motivation</h4> <p>Our work is motivated by an interest in constructing a protein-protein interaction network that captures key features associated with Parkinson’s disease. While there is an abundance of subnetwork construction methods available, it is often far from obvious which subnetwork is the most suitable starting point for further investigation.</p> <h4>Results</h4> <p>We provide a method to assess whether a subnetwork constructed from a seed list (a list of nodes known to be important in the area of interest) differs significantly from a randomly generated subnetwork. The proposed method uses a Monte Carlo approach. As different seed lists can give rise to the same subnetwork, we control for redundancy by constructing a minimal seed list as the starting point for the significance test. The null model is based on random seed lists of the same length as a minimum seed list that generates the subnetwork; in this random seed list the nodes have (approximately) the same degree distribution as the nodes in the minimum seed list. We use this null model to select subnetworks which deviate significantly from random on an appropriate set of statistics and might capture useful information for a real world protein-protein interaction network.</p> |
| first_indexed | 2024-03-07T03:22:11Z |
| format | Journal article |
| id | oxford-uuid:b7cf280e-3b90-4906-97ef-a7ef3cda7d04 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:22:11Z |
| publishDate | 2017 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:b7cf280e-3b90-4906-97ef-a7ef3cda7d042022-03-27T04:51:13ZA nonparametric significance test for sampled networksJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b7cf280e-3b90-4906-97ef-a7ef3cda7d04Symplectic Elements at OxfordOxford University Press2017Elliott, ALeicht, EWhitmore, AReinert, GReed-Tsochas, F <h4>Motivation</h4> <p>Our work is motivated by an interest in constructing a protein-protein interaction network that captures key features associated with Parkinson’s disease. While there is an abundance of subnetwork construction methods available, it is often far from obvious which subnetwork is the most suitable starting point for further investigation.</p> <h4>Results</h4> <p>We provide a method to assess whether a subnetwork constructed from a seed list (a list of nodes known to be important in the area of interest) differs significantly from a randomly generated subnetwork. The proposed method uses a Monte Carlo approach. As different seed lists can give rise to the same subnetwork, we control for redundancy by constructing a minimal seed list as the starting point for the significance test. The null model is based on random seed lists of the same length as a minimum seed list that generates the subnetwork; in this random seed list the nodes have (approximately) the same degree distribution as the nodes in the minimum seed list. We use this null model to select subnetworks which deviate significantly from random on an appropriate set of statistics and might capture useful information for a real world protein-protein interaction network.</p> |
| spellingShingle | Elliott, A Leicht, E Whitmore, A Reinert, G Reed-Tsochas, F A nonparametric significance test for sampled networks |
| title | A nonparametric significance test for sampled networks |
| title_full | A nonparametric significance test for sampled networks |
| title_fullStr | A nonparametric significance test for sampled networks |
| title_full_unstemmed | A nonparametric significance test for sampled networks |
| title_short | A nonparametric significance test for sampled networks |
| title_sort | nonparametric significance test for sampled networks |
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