Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer.

Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer.

Anemia has been implicated in the decreased oxygen tension noted within the tumor environment. In a series of 79 colorectal adenocarcinomas we investigated the role of anemia in activating molecular pathways regulated by hypoxia. Preoperative Hb levels were correlated with the immunohistochemical ex...

Full description

Bibliographic Details
Main Authors:	Koukourakis, M, Giatromanolaki, A, Polychronidis, A, Simopoulos, C, Gatter, K, Harris, A, Sivridis, E
Format:	Journal article
Language:	English
Published:	2006

Similar Items

Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas.
by: Giatromanolaki, A, et al.
Published: (2006)

c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent.
by: Giatromanolaki, A, et al.
Published: (2004)

Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas.
by: Giatromanolaki, A, et al.
Published: (2010)

Differential assessment of angiogenic activity and of vascular survival ability (VSA) in breast cancer.
by: Giatromanolaki, A, et al.
Published: (2002)

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia.
by: Koukourakis, M, et al.
Published: (2010)

Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer.
by: Koukourakis, M, et al.
Published: (2004)

Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease.
by: Giatromanolaki, A, et al.
Published: (2003)

BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis.
by: Giatromanolaki, A, et al.
Published: (2008)

Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.
by: Sivridis, E, et al.
Published: (2002)

Autophagy and hypoxia in colonic adenomas related to aggressive features.
by: Giatromanolaki, A, et al.
Published: (2013)

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer.
by: Koukourakis, M, et al.
Published: (2002)

Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients.
by: Koukourakis, M, et al.
Published: (2003)

Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group.
by: Koukourakis, M, et al.
Published: (2006)

Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin.
by: Giatromanolaki, A, et al.
Published: (2003)

BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer.
by: Giatromanolaki, A, et al.
Published: (2004)

Expression of phosphorylated (activated) receptors of vascular endothelial growth factor (VEGFR2/KDR) in colorectal cancer
by: Giatromanolaki, A, et al.
Published: (2007)

LYVE-1 immunohistochemical assessment of lymphangiogenesis in endometrial and lung cancer.
by: Koukourakis, M, et al.
Published: (2005)

Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins.
by: Giatromanolaki, A, et al.
Published: (2008)

Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation.
by: Giatromanolaki, A, et al.
Published: (2008)

Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.
by: Koukourakis, M, et al.
Published: (2003)

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
by: Giatromanolaki, A, et al.
Published: (2003)

Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis.
by: Giatromanolaki, A, et al.
Published: (2003)

Inclusion of vasculature-related variables in the Dukes staging system of colon cancer.
by: Koukourakis, M, et al.
Published: (2005)

High DLL4 expression in tumour-associated vessels predicts for favorable radiotherapy outcome in locally advanced squamous cell head-neck cancer (HNSCC).
by: Koukourakis, M, et al.
Published: (2013)

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
by: Koukourakis, M, et al.
Published: (2005)

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival.
by: Giatromanolaki, A, et al.
Published: (2001)

Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer.
by: Giatromanolaki, A, et al.
Published: (2007)

Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression.
by: Giatromanolaki, A, et al.
Published: (2006)

Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis.
by: Sivridis, E, et al.
Published: (2002)

Thermogenic protein UCP1 and UCP3 expression in non-small cell lung cancer: relation with glycolysis and anaerobic metabolism
by: Alexandra Giatromanolaki, et al.
Published: (2017-12-01)

Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas.
by: Giatromanolaki, A, et al.
Published: (2013)

The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer.
by: Giatromanolaki, A, et al.
Published: (2008)

Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma
by: Michael I. Koukourakis, et al.
Published: (2005-01-01)

Vascular density analysis in colorectal cancer patients treated with vatalanib (PTK787/ZK222584) in the randomised CONFIRM trials.
by: Giatromanolaki, A, et al.
Published: (2012)

C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer.
by: Koukourakis, M, et al.
Published: (2006)

Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas.
by: Sivridis, E, et al.
Published: (2002)

LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas.
by: Sivridis, E, et al.
Published: (2010)

Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy.
by: Koukourakis, M, et al.
Published: (2011)

Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines
by: Koukourakis, M, et al.
Published: (2015)

Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab.
by: Koukourakis, M, et al.
Published: (2009)