Palladium catalyzed tandem alkenyl- and aryl-C-N bond formation: a cascade N-annulation route to 4-, 5-, 6-and 7-chloroindoles
A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono-chloroindoles. 4-, 5-, 6- and 7-Chloroindoles can all be prepared; carbamates, anilines and amines can be employed as the N-nu...
| Main Authors: | , , |
|---|---|
| Format: | Conference item |
| Published: |
2010
|
| Summary: | A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono-chloroindoles. 4-, 5-, 6- and 7-Chloroindoles can all be prepared; carbamates, anilines and amines can be employed as the N-nucleophile. © 2010 Elsevier Ltd. |
|---|