Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia.
Acclimatization to altitude involves an increase in the acute hypoxic ventilatory response (AHVR). Because low-dose dopamine decreases AHVR and domperidone increases AHVR, the increase in AHVR at altitude may be generated by a decrease in peripheral dopaminergic activity. The AHVR of nine subjects w...
| Những tác giả chính: | , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
1999
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| _version_ | 1826293010943442944 |
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| author | Pedersen, M Dorrington, K Robbins, P |
| author_facet | Pedersen, M Dorrington, K Robbins, P |
| author_sort | Pedersen, M |
| collection | OXFORD |
| description | Acclimatization to altitude involves an increase in the acute hypoxic ventilatory response (AHVR). Because low-dose dopamine decreases AHVR and domperidone increases AHVR, the increase in AHVR at altitude may be generated by a decrease in peripheral dopaminergic activity. The AHVR of nine subjects was determined with and without a prior period of 8 h of isocapnic hypoxia under each of three pharmacological conditions: 1) control, with no drug administered; 2) dopamine (3 microg. min-1. kg-1); and 3) domperidone (Motilin, 40 mg). AHVR increased after hypoxia (P |
| first_indexed | 2024-03-07T03:23:31Z |
| format | Journal article |
| id | oxford-uuid:b83fed25-9769-4c4f-9d41-ae2cbd42b5a9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:23:31Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:b83fed25-9769-4c4f-9d41-ae2cbd42b5a92022-03-27T04:54:33ZEffects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b83fed25-9769-4c4f-9d41-ae2cbd42b5a9EnglishSymplectic Elements at Oxford1999Pedersen, MDorrington, KRobbins, PAcclimatization to altitude involves an increase in the acute hypoxic ventilatory response (AHVR). Because low-dose dopamine decreases AHVR and domperidone increases AHVR, the increase in AHVR at altitude may be generated by a decrease in peripheral dopaminergic activity. The AHVR of nine subjects was determined with and without a prior period of 8 h of isocapnic hypoxia under each of three pharmacological conditions: 1) control, with no drug administered; 2) dopamine (3 microg. min-1. kg-1); and 3) domperidone (Motilin, 40 mg). AHVR increased after hypoxia (P |
| spellingShingle | Pedersen, M Dorrington, K Robbins, P Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia. |
| title | Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia. |
| title_full | Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia. |
| title_fullStr | Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia. |
| title_full_unstemmed | Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia. |
| title_short | Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia. |
| title_sort | effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia |
| work_keys_str_mv | AT pedersenm effectsofdopamineanddomperidoneonventilatorysensitivitytohypoxiaafter8hofisocapnichypoxia AT dorringtonk effectsofdopamineanddomperidoneonventilatorysensitivitytohypoxiaafter8hofisocapnichypoxia AT robbinsp effectsofdopamineanddomperidoneonventilatorysensitivitytohypoxiaafter8hofisocapnichypoxia |