POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer

<strong>Purpose:</strong> Recent studies have shown that 7-12% of endometrial cancers (ECs) are ultramutated due to mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of the emerging data linking mut...

詳細記述

書誌詳細
主要な著者: Klenerman, P, Church, D, Tomlinson, I, van Gool, I, Eggink, F, Freeman-Mills, L, Stelloo, E, Marchi, E, de Bruyn, M, Palles, C, Nout, R, de Kroon, C, Osse, E, Creutzberg, C, Smit, V, Nijman, H, Bosse, T
フォーマット: Journal article
言語:English
出版事項: American Association for Cancer Research 2015