Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.

IL-18 inhibits osteoclast (OCL) formation in vitro independent of IFN-gamma production, and this was abolished by the addition of neutralizing antibodies to GM-CSF. We now establish that IL-18 was unable to inhibit OCL formation in cocultures using GM-CSF-deficient mice (GM-CSF -/-). Reciprocal cocu...

Полное описание

Библиографические подробности
Главные авторы: Horwood, N, Udagawa, N, Elliott, J, Grail, D, Okamura, H, Kurimoto, M, Dunn, A, Martin, T, Gillespie, M
Формат: Journal article
Язык:English
Опубликовано: 1998