The clinical pharmacology of thioguanine vs. mercaptopurine in ALL97, a randomized trial for the treatment of childhood lymphoblastic leukaemia

The clinical pharmacology of thioguanine vs. mercaptopurine in ALL97, a randomized trial for the treatment of childhood lymphoblastic leukaemia

Bibliographic Details
Main Authors:	Lennard, L, Cartwright, C, Wade, R, Richards, S, Mitchell, C, Kinsey, S, Eden, O, Vora, A
Format:	Conference item
Published:	2008

Similar Items

Thioguanine compared with mercaptopurine in childhood lymphoblastic leukaemia: Results of the United Kingdom medical research council randomised trial ALL97.
by: Lennard, L, et al.
Published: (2005)

Thioguanine versus mercaptopurine in ALL97: thiopurine metabolism and treatment outcome
by: Lennard, L, et al.
Published: (2008)

Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.
by: Vora, A, et al.
Published: (2006)

MRC ALL97/99 - A randomized comparison of dexamethasone versus prednisolone and thioguanine versus mercaptopurine in the treatment of childhood acute lymphoblastic leukemia.
by: Mitchell, C, et al.
Published: (2002)

Thioguanine-related veno-occlusive disease (VOD) of the liver in children with acute lymphoblastic leukaemia (ALL): Report from United Kingdom Medical Research Council (UK MRC) trial ALL97.
by: Vora, A, et al.
Published: (2002)

The thiopurine methyltransferase TPMT *1/*3A genotype is associated with a better treatment outcome in the UK ALL97 trial for childhood acute lymphoblastic leukaemia; TPMT heterozygosity is not associated with secondary cancers
by: Lennard, L, et al.
Published: (2010)

The impact of risk stratification by early bone-marrow response in childhood lymphoblastic leukaemia: results from the United Kingdom Medical Research Council trial ALL97 and ALL97/99.
by: Mitchell, C, et al.
Published: (2009)

Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial.
by: Mitchell, C, et al.
Published: (2005)

Benefit of targeted intensification for NCI high risk childhood lymphoblastic leukaemia: Results of the United Kingdom medical research council trial ALL97 and ALL97/99.
by: Vora, A, et al.
Published: (2006)

Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.
by: Lennard, L, et al.
Published: (2013)

The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.
by: Lennard, L, et al.
Published: (2006)

Prognostic Relevance of Cytogenetics in Childhood Acute Lymphoblastic Leukaemia (ALL): Final Results From MRC ALL97.
by: Moor-Man, A, et al.
Published: (2009)

Benefit of intensified treatment for all children with acute lymphoblastic leukaemia: results from MRC UKALL XI and MRC ALL97 randomised trials. UK Medical Research Council's Working Party on Childhood Leukaemia.
by: Hann, I, et al.
Published: (2000)

Intraocular relapse of childhood acute lymphoblastic leukaemia.
by: Somervaille, T, et al.
Published: (2003)

Late relapsing childhood lymphoblastic leukaemia.
by: Frost, L, et al.
Published: (1997)

Variables affecting kinetics of minimal residual disease clearance in children with lymphoblastic leukaemia; Results of the United Kingdom Medical Research Council (UK MRC) protocols ALL97, ALL97/99 and ALL2003.
by: Vora, A, et al.
Published: (2005)

Treatment of high risk leukaemia - Results of MRC childhood acute lymphoblastic leukaemia study MRC HR-1.
by: Kinsey, S, et al.
Published: (2002)

Late relapsing childhood acute lymphoblastic leukaemia.
by: Frost, L, et al.
Published: (1998)

Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial.
by: Moorman, A, et al.
Published: (2010)

Pharmacological and toxicological effects of 6-hydroxy-2-mercaptopurine and 6-thioguanine in in vitro and in vivo models of arthritis
by: Nordin, Nurul Syuhada
Published: (2021)

Effect of maintenance therapy for childhood with acute lymphoblastic leukaemia by combination of methotrexate and 6–mercaptopurine on the liver.
by: Abid T. Firas, et al.
Published: (2005-12-01)

Acute lymphoblastic leukaemia has a poor outcome in children with Down syndrome due to infective death in remission - (Results of UK MRC ALL 97 trial).
by: de la Fuente, J, et al.
Published: (2005)

Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: A systematic review.
by: Linea Natalie Toksvang, et al.
Published: (2019-01-01)

Blast cell vacuoles in childhood lymphoblastic leukaemia.
by: Lilleyman, J, et al.
Published: (1988)

TEL-AML1 fusion in childhood acute lymphoblastic leukaemia (ALL): Demographics, clinical features, cytogenetic characteristics and prognosis
by: Moorman, A, et al.
Published: (2005)

Karyotype and prognosis in childhood acute lymphoblastic leukemia (ALL) in the UK medical research council (MRC) ALL97 trial.
by: Moorman, A, et al.
Published: (2003)

Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials.
by: Ramanujachar, R, et al.
Published: (2007)

Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001.
by: Krishnan, S, et al.
Published: (2010)

Delineation of Risk Factors in Paediatric Acute Lymphoblastic Leukaemia with Favourable Cytogenetics
by: Moorman, A, et al.
Published: (2012)

Testicular irradiation in childhood lymphoblastic leukaemia. Medical Research Council Working Party on Leukemia in Childhoods.
by: Eden, O, et al.
Published: (1990)

Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001.
by: Mitchell, C, et al.
Published: (2010)

Long survival in childhood lymphoblastic leukaemia.
by: Chessells, J, et al.
Published: (1987)

Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia.
by: Escherich, G, et al.
Published: (2011)

Cytogenetic-specific heterogeneity in the kinetics of minimal residual disease (MIRD) clearance in childhood lymphoblastic leukaemia (ALL)
by: Moorman, A, et al.
Published: (2008)

Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia
by: Escherich, G, et al.
Published: (2011)

Intraocular relapse of childhood acute lymphoblastic leukemia.
by: Somervaille, T, et al.
Published: (2002)

Gender and treatment outcome in childhood lymphoblastic leukaemia: report from the MRC UKALL trials.
by: Chessells, J, et al.
Published: (1995)

Relationship between HLA-DP supertype and survival in childhood acute lymphoblastic leukaemia: evidence for selective loss of immunological control of residual disease?
by: Taylor, G, et al.
Published: (2009)

Cytogenetic-specific heterogeneity in the kinetics of minimal residual disease (MRD) clearance in childhood acute lymphoblastic leukaemia (ALL)
by: Moorman, A, et al.
Published: (2007)

No association of HLA-A supertype with outcome in childhood acute lymphoblastic leukaemia: results of the UKALL XI trial.
by: Thompson, P, et al.
Published: (2011)