Structural and biochemical characterisation of human integral membrane proteins regarded as potential therapeutic targets

Structural and biochemical characterisation of human integral membrane proteins regarded as potential therapeutic targets

<p>Integral membrane proteins are responsible for a wide range of cellular functions and are important targets for the development of novel therapeutics. Therefore, obtaining structural and mechanistic insights into their function is of central importance for rational drug design. In this thes...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	da Costa Cabral Gomes Páscoa, T
Awduron Eraill:	Carpenter, E
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2022
Pynciau:	Biochemistry Structural Biology

Eitemau Tebyg

Biochemical characterisation of KDM2A
gan: Zhou, JC
Cyhoeddwyd: (2012)

Characterisation of 2-oxoglutarate- and fe(II)-dependent oxygenases targeting the protein synthesis apparatus
gan: Feng, T
Cyhoeddwyd: (2014)

Structural characterisation of calnexin cycle components and assessment as antiviral targets
gan: Hill, J
Cyhoeddwyd: (2018)

Identification and characterisation of alternative forms of SETD2/HYPB (SET domain-containing protein 2 / Huntingtin yeast partner B)
gan: Lee, BM
Cyhoeddwyd: (2011)

Biochemical studies of the cohesin complex
gan: Upcher, WR
Cyhoeddwyd: (2012)

Biochemical and functional characterization of the RNA binding protein SAF-A/hnRNP U and investigation of its potential role in mammalian X chromosome inactivation
gan: Tattermusch, A
Cyhoeddwyd: (2015)

Cryo-EM grid optimization for membrane proteins
gan: Domen Kampjut, et al.
Cyhoeddwyd: (2021-03-01)

Structual and biochemical characterisation of the endoplasmic reticulum alpha-glucosidases
gan: Caputo, A
Cyhoeddwyd: (2015)

Mass Photometry of Membrane Proteins
gan: Olerinyova, A, et al.
Cyhoeddwyd: (2020)

Structural & biophysical characterisation of M. tuberculosis MmpL3
gan: Adams, O
Cyhoeddwyd: (2021)

Structural and biophysical characterisation of marine viruses and amino acid transporters
gan: Gillum, A
Cyhoeddwyd: (2018)

Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis
gan: Lee, Bei Shi, et al.
Cyhoeddwyd: (2020)

Role of mutual information for predicting contact residues in proteins
gan: Gomes, M
Cyhoeddwyd: (2012)

Biochemical, structural and functional analysis of an engineered DNA architectural protein
gan: Bao, Qiuye
Cyhoeddwyd: (2008)

Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome
gan: Natalie M. Hendrikse, et al.
Cyhoeddwyd: (2021-03-01)

Aging and cancer hallmarks as therapeutic targets
gan: Jingchao Wang, et al.
Cyhoeddwyd: (2023-07-01)

Biochemical study of the interactions between cohesin and DNA
gan: Collier, JE
Cyhoeddwyd: (2020)

Structural and biochemical study of Candida albicans polarisomal proteins
gan: Loh, Zhi Yang
Cyhoeddwyd: (2021)

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
gan: Nanaka Kaneshiro, et al.
Cyhoeddwyd: (2022-03-01)

Structural studies of integral membrane GPCR accessory proteins
gan: Sladek, B
Cyhoeddwyd: (2013)

Molecular modeling and simulation for proteins and polymer membranes
gan: Christian, Bope Domilongo
Cyhoeddwyd: (2017)

Fluorescence spectroscopy in biology : advanced methods and their applications to membranes, proteins, DNA, and cells /
gan: Fidler, V., et al.
Cyhoeddwyd: (2005)

Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
gan: Chuanxu Liu, et al.
Cyhoeddwyd: (2023-08-01)

Expression of an inverted repeat of a target gene leads to specific disappearance of the corresponding mRNA and encoded protein.
gan: Bastin, P, et al.
Cyhoeddwyd: (1999)

Characterisation of ant-1 as an inhibitor of myostatin activity.
gan: Irfana Begum Ikbal.
Cyhoeddwyd: (2011)

Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target
gan: Beuerman, Roger W., et al.
Cyhoeddwyd: (2013)

Investigating the non-protein binding targets of the Teneurin extracellular domain and their biological significance
gan: Crowther, O
Cyhoeddwyd: (2022)

Characterisation of the influenza virus matrix protein M1 and its role in oligomerisation
gan: Mohd Kipli, MFH
Cyhoeddwyd: (2020)

Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling
gan: Abigail Brewer, et al.
Cyhoeddwyd: (2024-08-01)

Construction and characterisation of a siclopps cyclic peptide library.
gan: Koh, Ethel Rui Li.
Cyhoeddwyd: (2010)

Structural and functional characterisation of the fungal plasma membrane proton pump, Pma1, and related P-Type ATPases
gan: Geurts, MMG
Cyhoeddwyd: (2022)

Tryptophan-dependent membrane interaction and heteromerization with the internal fusion peptide by the membrane proximal external region of SARS-CoV spike protein
gan: Liao, Ying, et al.
Cyhoeddwyd: (2015)

A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain
gan: Baowen Liu, et al.
Cyhoeddwyd: (2023-06-01)

Memprotmd: adding the grease to membrane protein structures
gan: Stansfeld, P, et al.
Cyhoeddwyd: (2012)

Fundamentals of biochemical calculations /
gan: 410239 Moorthy, Krish
Cyhoeddwyd: (2008)

Methods of biochemical analysis/
gan: Glick, David
Cyhoeddwyd: (1954)

Protocol to identify multiple protein targets and therapeutic compounds using an in silico polypharmacological approach
gan: Akshaya Simha N, et al.
Cyhoeddwyd: (2023-09-01)

Characterisation of novel metabolically-stable peptides from chenopodium quinoa
gan: Ng, Jaclyn Cheah Yee
Cyhoeddwyd: (2018)

Characterisation of Kindlin-3 and RACK1 interaction in integrin signaling.
gan: Lee, Huishan.
Cyhoeddwyd: (2011)

Biochemical and structural studies on the molecular interaction between P53 transcriptional activation domain and anti-apoptotic protein BCL-XL
gan: Xu, Huibin
Cyhoeddwyd: (2009)