Structural and biochemical characterisation of human integral membrane proteins regarded as potential therapeutic targets

Structural and biochemical characterisation of human integral membrane proteins regarded as potential therapeutic targets

<p>Integral membrane proteins are responsible for a wide range of cellular functions and are important targets for the development of novel therapeutics. Therefore, obtaining structural and mechanistic insights into their function is of central importance for rational drug design. In this thes...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	da Costa Cabral Gomes Páscoa, T
Rannpháirtithe:	Carpenter, E
Formáid:	Tráchtas
Teanga:	English
Foilsithe / Cruthaithe:	2022
Ábhair:	Biochemistry Structural Biology

Míreanna comhchosúla

Biochemical characterisation of KDM2A
de réir: Zhou, JC
Foilsithe / Cruthaithe: (2012)

Characterisation of 2-oxoglutarate- and fe(II)-dependent oxygenases targeting the protein synthesis apparatus
de réir: Feng, T
Foilsithe / Cruthaithe: (2014)

Structural characterisation of calnexin cycle components and assessment as antiviral targets
de réir: Hill, J
Foilsithe / Cruthaithe: (2018)

Identification and characterisation of alternative forms of SETD2/HYPB (SET domain-containing protein 2 / Huntingtin yeast partner B)
de réir: Lee, BM
Foilsithe / Cruthaithe: (2011)

Biochemical studies of the cohesin complex
de réir: Upcher, WR
Foilsithe / Cruthaithe: (2012)

Biochemical and functional characterization of the RNA binding protein SAF-A/hnRNP U and investigation of its potential role in mammalian X chromosome inactivation
de réir: Tattermusch, A
Foilsithe / Cruthaithe: (2015)

Cryo-EM grid optimization for membrane proteins
de réir: Domen Kampjut, et al.
Foilsithe / Cruthaithe: (2021-03-01)

Structual and biochemical characterisation of the endoplasmic reticulum alpha-glucosidases
de réir: Caputo, A
Foilsithe / Cruthaithe: (2015)

Mass Photometry of Membrane Proteins
de réir: Olerinyova, A, et al.
Foilsithe / Cruthaithe: (2020)

Structural & biophysical characterisation of M. tuberculosis MmpL3
de réir: Adams, O
Foilsithe / Cruthaithe: (2021)

Structural and biophysical characterisation of marine viruses and amino acid transporters
de réir: Gillum, A
Foilsithe / Cruthaithe: (2018)

Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis
de réir: Lee, Bei Shi, et al.
Foilsithe / Cruthaithe: (2020)

Role of mutual information for predicting contact residues in proteins
de réir: Gomes, M
Foilsithe / Cruthaithe: (2012)

Biochemical, structural and functional analysis of an engineered DNA architectural protein
de réir: Bao, Qiuye
Foilsithe / Cruthaithe: (2008)

Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome
de réir: Natalie M. Hendrikse, et al.
Foilsithe / Cruthaithe: (2021-03-01)

Aging and cancer hallmarks as therapeutic targets
de réir: Jingchao Wang, et al.
Foilsithe / Cruthaithe: (2023-07-01)

Biochemical study of the interactions between cohesin and DNA
de réir: Collier, JE
Foilsithe / Cruthaithe: (2020)

Structural and biochemical study of Candida albicans polarisomal proteins
de réir: Loh, Zhi Yang
Foilsithe / Cruthaithe: (2021)

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
de réir: Nanaka Kaneshiro, et al.
Foilsithe / Cruthaithe: (2022-03-01)

Structural studies of integral membrane GPCR accessory proteins
de réir: Sladek, B
Foilsithe / Cruthaithe: (2013)

Molecular modeling and simulation for proteins and polymer membranes
de réir: Christian, Bope Domilongo
Foilsithe / Cruthaithe: (2017)

Fluorescence spectroscopy in biology : advanced methods and their applications to membranes, proteins, DNA, and cells /
de réir: Fidler, V., et al.
Foilsithe / Cruthaithe: (2005)

Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
de réir: Chuanxu Liu, et al.
Foilsithe / Cruthaithe: (2023-08-01)

Expression of an inverted repeat of a target gene leads to specific disappearance of the corresponding mRNA and encoded protein.
de réir: Bastin, P, et al.
Foilsithe / Cruthaithe: (1999)

Characterisation of ant-1 as an inhibitor of myostatin activity.
de réir: Irfana Begum Ikbal.
Foilsithe / Cruthaithe: (2011)

Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target
de réir: Beuerman, Roger W., et al.
Foilsithe / Cruthaithe: (2013)

Investigating the non-protein binding targets of the Teneurin extracellular domain and their biological significance
de réir: Crowther, O
Foilsithe / Cruthaithe: (2022)

Characterisation of the influenza virus matrix protein M1 and its role in oligomerisation
de réir: Mohd Kipli, MFH
Foilsithe / Cruthaithe: (2020)

Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling
de réir: Abigail Brewer, et al.
Foilsithe / Cruthaithe: (2024-08-01)

Construction and characterisation of a siclopps cyclic peptide library.
de réir: Koh, Ethel Rui Li.
Foilsithe / Cruthaithe: (2010)

Structural and functional characterisation of the fungal plasma membrane proton pump, Pma1, and related P-Type ATPases
de réir: Geurts, MMG
Foilsithe / Cruthaithe: (2022)

Tryptophan-dependent membrane interaction and heteromerization with the internal fusion peptide by the membrane proximal external region of SARS-CoV spike protein
de réir: Liao, Ying, et al.
Foilsithe / Cruthaithe: (2015)

A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain
de réir: Baowen Liu, et al.
Foilsithe / Cruthaithe: (2023-06-01)

Memprotmd: adding the grease to membrane protein structures
de réir: Stansfeld, P, et al.
Foilsithe / Cruthaithe: (2012)

Fundamentals of biochemical calculations /
de réir: 410239 Moorthy, Krish
Foilsithe / Cruthaithe: (2008)

Methods of biochemical analysis/
de réir: Glick, David
Foilsithe / Cruthaithe: (1954)

Protocol to identify multiple protein targets and therapeutic compounds using an in silico polypharmacological approach
de réir: Akshaya Simha N, et al.
Foilsithe / Cruthaithe: (2023-09-01)

Characterisation of novel metabolically-stable peptides from chenopodium quinoa
de réir: Ng, Jaclyn Cheah Yee
Foilsithe / Cruthaithe: (2018)

Characterisation of Kindlin-3 and RACK1 interaction in integrin signaling.
de réir: Lee, Huishan.
Foilsithe / Cruthaithe: (2011)

Biochemical and structural studies on the molecular interaction between P53 transcriptional activation domain and anti-apoptotic protein BCL-XL
de réir: Xu, Huibin
Foilsithe / Cruthaithe: (2009)