Co-localisation of abnormal brain structure and function in specific language impairment
We assessed the relationship between brain structure and function in 10 individuals with specific language impairment (SLI), compared to six unaffected siblings, and 16 unrelated control participants with typical language. Voxel-based morphometry indicated that grey matter in the SLI group, relative...
| Autori principali: | , , , , |
|---|---|
| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
2012
|
| _version_ | 1826293070853832704 |
|---|---|
| author | Badcock, N Bishop, D Hardiman, M Barry, J Watkins, K |
| author_facet | Badcock, N Bishop, D Hardiman, M Barry, J Watkins, K |
| author_sort | Badcock, N |
| collection | OXFORD |
| description | We assessed the relationship between brain structure and function in 10 individuals with specific language impairment (SLI), compared to six unaffected siblings, and 16 unrelated control participants with typical language. Voxel-based morphometry indicated that grey matter in the SLI group, relative to controls, was increased in the left inferior frontal cortex and decreased in the right caudate nucleus and superior temporal cortex bilaterally. The unaffected siblings also showed reduced grey matter in the caudate nucleus relative to controls. In an auditory covert naming task, the SLI group showed reduced activation in the left inferior frontal cortex, right putamen, and in the superior temporal cortex bilaterally. Despite spatially coincident structural and functional abnormalities in frontal and temporal areas, the relationships between structure and function in these regions were different. These findings suggest multiple structural and functional abnormalities in SLI that are differently associated with receptive and expressive language processing. © 2011 Elsevier Inc. |
| first_indexed | 2024-03-07T03:24:26Z |
| format | Journal article |
| id | oxford-uuid:b88b08a8-3e4d-45b2-abfa-fc8677e71c5a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:24:26Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:b88b08a8-3e4d-45b2-abfa-fc8677e71c5a2022-03-27T04:56:36ZCo-localisation of abnormal brain structure and function in specific language impairmentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b88b08a8-3e4d-45b2-abfa-fc8677e71c5aEnglishSymplectic Elements at Oxford2012Badcock, NBishop, DHardiman, MBarry, JWatkins, KWe assessed the relationship between brain structure and function in 10 individuals with specific language impairment (SLI), compared to six unaffected siblings, and 16 unrelated control participants with typical language. Voxel-based morphometry indicated that grey matter in the SLI group, relative to controls, was increased in the left inferior frontal cortex and decreased in the right caudate nucleus and superior temporal cortex bilaterally. The unaffected siblings also showed reduced grey matter in the caudate nucleus relative to controls. In an auditory covert naming task, the SLI group showed reduced activation in the left inferior frontal cortex, right putamen, and in the superior temporal cortex bilaterally. Despite spatially coincident structural and functional abnormalities in frontal and temporal areas, the relationships between structure and function in these regions were different. These findings suggest multiple structural and functional abnormalities in SLI that are differently associated with receptive and expressive language processing. © 2011 Elsevier Inc. |
| spellingShingle | Badcock, N Bishop, D Hardiman, M Barry, J Watkins, K Co-localisation of abnormal brain structure and function in specific language impairment |
| title | Co-localisation of abnormal brain structure and function in specific language impairment |
| title_full | Co-localisation of abnormal brain structure and function in specific language impairment |
| title_fullStr | Co-localisation of abnormal brain structure and function in specific language impairment |
| title_full_unstemmed | Co-localisation of abnormal brain structure and function in specific language impairment |
| title_short | Co-localisation of abnormal brain structure and function in specific language impairment |
| title_sort | co localisation of abnormal brain structure and function in specific language impairment |
| work_keys_str_mv | AT badcockn colocalisationofabnormalbrainstructureandfunctioninspecificlanguageimpairment AT bishopd colocalisationofabnormalbrainstructureandfunctioninspecificlanguageimpairment AT hardimanm colocalisationofabnormalbrainstructureandfunctioninspecificlanguageimpairment AT barryj colocalisationofabnormalbrainstructureandfunctioninspecificlanguageimpairment AT watkinsk colocalisationofabnormalbrainstructureandfunctioninspecificlanguageimpairment |