Structural basis of antifolate recognition and transport by PCFT

Folates (also known as vitamin B9) have a critical role in cellular metabolism as the starting point in the synthesis of nucleic acids, amino acids and the universal methylating agent S-adenylsmethionine1,2. Folate deficiency is associated with a number of developmental, immune and neurological diso...

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Detalles Bibliográficos
Main Authors: Parker, JL, Deme, JC, Kuteyi, G, Wu, Z, Huo, J, Goldman, ID, Owens, RJ, Biggin, PC, Lea, SM, Newstead, S
Formato: Journal article
Idioma:English
Publicado: Springer Nature 2021