Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

We have investigated the effects of the novel imidazoline compound (+)-2-(2-(4,5-dihydro-1H-imidazol-2-yl)-thiopene-2-yl-ethyl)-pyridine (NNC77-0074) on stimulus-secretion coupling in isolated pancreatic alpha- and beta-cells. NNC77-0074 stimulated glucose-dependent insulin secretion in intact mouse...

Full description

Bibliographic Details
Main Authors: Høy, M, Olsen, H, Andersen, H, Bokvist, K, Buschard, K, Hansen, J, Jacobsen, P, Petersen, J, Rorsman, P, Gromada, J
Format: Journal article
Language:English
Published: 2003

Similar Items

Similar Items