The oxazolomycins: a structurally novel class of bioactive compounds.
Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. Th...
| Príomhchruthaitheoirí: | , , , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2004
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| _version_ | 1826293090963423232 |
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| author | Moloney, M Trippier, P Yaqoob, M Wang, Z |
| author_facet | Moloney, M Trippier, P Yaqoob, M Wang, Z |
| author_sort | Moloney, M |
| collection | OXFORD |
| description | Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action. |
| first_indexed | 2024-03-07T03:24:44Z |
| format | Journal article |
| id | oxford-uuid:b8a7ae70-0f3b-42b3-a38b-b64eaabdfd9c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:24:44Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:b8a7ae70-0f3b-42b3-a38b-b64eaabdfd9c2022-03-27T04:57:17ZThe oxazolomycins: a structurally novel class of bioactive compounds.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b8a7ae70-0f3b-42b3-a38b-b64eaabdfd9cEnglishSymplectic Elements at Oxford2004Moloney, MTrippier, PYaqoob, MWang, ZOxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action. |
| spellingShingle | Moloney, M Trippier, P Yaqoob, M Wang, Z The oxazolomycins: a structurally novel class of bioactive compounds. |
| title | The oxazolomycins: a structurally novel class of bioactive compounds. |
| title_full | The oxazolomycins: a structurally novel class of bioactive compounds. |
| title_fullStr | The oxazolomycins: a structurally novel class of bioactive compounds. |
| title_full_unstemmed | The oxazolomycins: a structurally novel class of bioactive compounds. |
| title_short | The oxazolomycins: a structurally novel class of bioactive compounds. |
| title_sort | oxazolomycins a structurally novel class of bioactive compounds |
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