Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice.
Transgenic mice have been constructed expressing high (CD45RABC) and low (CD45R0) molecular weight CD45 isoforms on a CD45-/- background. Phenotypic analysis and in vivo challenge of these mice with influenza and lymphocytic choriomeningitis viruses shows that T cell differentiation and peripheral T...
| المؤلفون الرئيسيون: | , , , , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2004
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| _version_ | 1826293093487345664 |
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| author | Tchilian, E Dawes, R Hyland, L Montoya, M Le Bon, A Borrow, P Hou, S Tough, D Beverley, P |
| author_facet | Tchilian, E Dawes, R Hyland, L Montoya, M Le Bon, A Borrow, P Hou, S Tough, D Beverley, P |
| author_sort | Tchilian, E |
| collection | OXFORD |
| description | Transgenic mice have been constructed expressing high (CD45RABC) and low (CD45R0) molecular weight CD45 isoforms on a CD45-/- background. Phenotypic analysis and in vivo challenge of these mice with influenza and lymphocytic choriomeningitis viruses shows that T cell differentiation and peripheral T cell function are related to the level of CD45 expression but not to which CD45 isoform is expressed. In contrast, B cell differentiation is not restored, irrespective of the level of expression of a single isoform. All CD45 trangenic mice have T cells with an activated phenotype and increased T cell turnover. These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals. |
| first_indexed | 2024-03-07T03:24:46Z |
| format | Journal article |
| id | oxford-uuid:b8ab5d3a-291b-4d76-b8d3-f6fc52eb0e11 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:24:46Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:b8ab5d3a-291b-4d76-b8d3-f6fc52eb0e112022-03-27T04:57:27ZAltered CD45 isoform expression affects lymphocyte function in CD45 Tg mice.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b8ab5d3a-291b-4d76-b8d3-f6fc52eb0e11EnglishSymplectic Elements at Oxford2004Tchilian, EDawes, RHyland, LMontoya, MLe Bon, ABorrow, PHou, STough, DBeverley, PTransgenic mice have been constructed expressing high (CD45RABC) and low (CD45R0) molecular weight CD45 isoforms on a CD45-/- background. Phenotypic analysis and in vivo challenge of these mice with influenza and lymphocytic choriomeningitis viruses shows that T cell differentiation and peripheral T cell function are related to the level of CD45 expression but not to which CD45 isoform is expressed. In contrast, B cell differentiation is not restored, irrespective of the level of expression of a single isoform. All CD45 trangenic mice have T cells with an activated phenotype and increased T cell turnover. These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals. |
| spellingShingle | Tchilian, E Dawes, R Hyland, L Montoya, M Le Bon, A Borrow, P Hou, S Tough, D Beverley, P Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. |
| title | Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. |
| title_full | Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. |
| title_fullStr | Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. |
| title_full_unstemmed | Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. |
| title_short | Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice. |
| title_sort | altered cd45 isoform expression affects lymphocyte function in cd45 tg mice |
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