The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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Bibliografiske detaljer
Main Authors:	Chowdhury, R, Yeoh, K, Tian, Y, Hillringhaus, L, Bagg, E, Rose, N, Leung, I, Li, X, Woon, E, Yang, M, McDonough, M, King, O, Clifton, I, Klose, R, Claridge, T, Ratcliffe, P, Schofield, C, Kawamura, A
Format:	Journal article
Udgivet:	2011

Lignende værker

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
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Udgivet: (2011)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
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Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases
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Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
af: Rose, N, et al.
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Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
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Focused screening identifies different sensitivities of human TET oxygenases to the oncometabolite 2-hydroxyglutarate
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The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
af: Carbonneau, M, et al.
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Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.
af: Walport, L, et al.
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Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate
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The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
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Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
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The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites
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Chemical probes for histone lysine demethylases
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Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.
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Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
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In vitro enzyme assays for JmjC-domain-containing lysine histone demethylases (JmjC-KDMs)
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Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
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Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
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Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
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Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
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CpG islands recruit a histone H3 lysine 36 demethylase.
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Androgen receptor and histone lysine demethylases in ovine placenta.
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Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
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Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase
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Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
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Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).
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Recent progress in histone demethylase inhibitors
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Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean
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Oncometabolites D- and L-2-hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions
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Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
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Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A
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Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia
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The oncometabolite R-2-hydroxyglutarate dysregulates the differentiation of human mesenchymal stromal cells via inducing DNA hypermethylation
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Histone demethylases in chromatin biology and beyond
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Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics
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Epigenetic Control of Muscle Stem Cells: Focus on Histone Lysine Demethylases
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