Single-molecule, super-resolution, and functional analysis of G protein-coupled receptor behavior within the T cell immunological synapse

Single-molecule, super-resolution, and functional analysis of G protein-coupled receptor behavior within the T cell immunological synapse

A central process in immunity is the activation of T cells through interaction of T cell receptors (TCRs) with agonistic peptide-major histocompatibility complexes (pMHC) on the surface of antigen presenting cells (APCs). TCR-pMHC binding triggers the formation of an extensive contact between the tw...

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Bibliographic Details
Main Authors: Felce, JH, Parolini, L, Sezgin, E, Céspedes, PF, Korobchevskaya, K, Jones, M, Peng, Y, Dong, T, Fritzsche, M, Aarts, D, Frater, J, Dustin, ML
Format: Journal article
Language:English
Published: Frontiers Media 2020

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