DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation

Tudor-interacting repair regulator (TIRR) is an RNA-binding protein and a negative regulator of the DNA-repair factor p53-binding protein 1 (53BP1). In non-damage conditions, TIRR is bound to 53BP1. After DNA damage, TIRR and 53BP1 dissociate, and 53BP1 binds the chromatin at the double-strand break...

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Bibliographic Details
Main Authors:	Ketley, RF, Battistini, F, Alagia, A, Mondielli, C, Iehl, F, Balikçi, E, Huber, KVM, Orozco, M, Gullerova, M
Format:	Journal article
Language:	English
Published:	Cell Press 2022

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