3-fluoroazetidinecarboxylic acids and trans,trans-3,4-difluoroproline as peptide scaffolds: inhibition of pancreatic cancer cell growth by a fluoroazetidine iminosugar

3-fluoroazetidinecarboxylic acids and trans,trans-3,4-difluoroproline as peptide scaffolds: inhibition of pancreatic cancer cell growth by a fluoroazetidine iminosugar

Reverse aldol opening renders amides of 3-hydroxyazetidinecarboxylic acids (3-OH-Aze) unstable above pH 8. Aze, found in sugar beet, is mis-incorporated for proline in peptides in humans and is associated with multiple sclerosis and teratogenesis. Aze-containing peptides may be oxygenated by prolyl...

Podrobná bibliografie
Hlavní autoři:	Liu, Z, Jenkinson, S, Vermaas, T, Adachi, I, Wormald, M, Hata, Y, Kurashima, Y, Kaji, A, Yu, C, Kato, A, Fleet, G
Médium:	Journal article
Jazyk:	English
Vydáno:	American Chemical Society 2015

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