5-Formylcytosine does not change the global structure of DNA

5-Formylcytosine does not change the global structure of DNA

The mechanism by which 5-formylcytosine (fC) is recognised by enzymes involved in epigenetic modification and reading of DNA is not known, and recently an unusual DNA structure (F-DNA) was proposed as the basis for enzyme recognition of clusters of fC. We used NMR and X-ray crystallography to compar...

书目详细资料
Main Authors:	Hardwick, J, Ptchelkine, D, El-Sagheer, A, Tear, I, Singleton, D, Phillips, S, Lane, A, Brown, T
格式:	Journal article
出版:	Nature Publishing Group 2017

相似书籍

5-Formylcytosine: a new epigenetic player
由: Dharmendra Kumar, et al.
出版: (2024-10-01)

Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine
由: Brittani L. Schnable, et al.
出版: (2024-10-01)

Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships.
由: Daniel Gackowski, et al.
出版: (2015-01-01)

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis
由: Hardwick, JS, et al.
出版: (2020)

5-Formylcytosine landscapes of human preimplantation embryos at single-cell resolution.
由: Yun Gao, et al.
出版: (2020-07-01)

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro
由: Bian, Ke, et al.
出版: (2020)

Domain-knowledge enabled ensemble learning of 5-formylcytosine (f5C) modification sites
由: Jiaming Huang, et al.
出版: (2024-12-01)

Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5‐Formylcytosine Modification in Mitochondrial tRNAMet
由: Lindsey Van Haute, et al.
出版: (2017-03-01)

5-formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively
由: Daniel Gackowski, et al.
出版: (2020-05-01)

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.
由: Abdullah, U, et al.
出版: (2017)

RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks
由: Abdullah, U, et al.
出版: (2017)

Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer
由: Tine Maj Storebjerg, et al.
出版: (2018-08-01)

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting
由: Klimkowski, P, et al.
出版: (2019)

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors
由: Thomas, A, et al.
出版: (2019)

Epigenetic modifications of cytosine: biophysical properties, regulation, and function in mammalian DNA
由: Hardwick, J, et al.
出版: (2018)

Click chemistry with DNA.
由: El-Sagheer, A, et al.
出版: (2010)

A very stable cyclic DNA miniduplex with just two base pairs.
由: El-Sagheer, A, et al.
出版: (2008)

A triazole linkage that mimics the DNA phosphodiester group in living systems
由: El-Sagheer, A, et al.
出版: (2015)

Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation.
由: Thalhammer, A, et al.
出版: (2011)

Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility
由: El-Sagheer, A, et al.
出版: (2014)

Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template.
由: el-Sagheer, A, et al.
出版: (2011)

Searching for the ideal triazole: investigating the 1,5-triazole as a charge neutral DNA backbone mimic
由: Baker, YR, et al.
出版: (2019)

Synthesis and polymerase chain reaction amplification of DNA strands containing an unnatural triazole linkage.
由: El-Sagheer, A, et al.
出版: (2009)

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
由: Jenkins, T, et al.
出版: (2021)

Rapid and efficient DNA strand cross-linking by click chemistry.
由: Kocalka, P, et al.
出版: (2008)

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above
由: Walsh, S, et al.
出版: (2018)

Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry.
由: Shelbourne, M, et al.
出版: (2012)

Assessing the biocompatibility of click-linked DNA in Escherichia coli.
由: Sanzone, A, et al.
出版: (2012)

Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli.
由: El-Sagheer, A, et al.
出版: (2011)

Azide and trans-cyclooctene dUTPs: incorporation into DNA probes and fluorescent click-labelling.
由: Ren, X, et al.
出版: (2015)

The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications.
由: Gyi, J, et al.
出版: (2003)

Combination probes with intercalating anchors and proximal fluorophores for DNA and RNA detection.
由: Qiu, J, et al.
出版: (2016)

Reversible ligation of programmed DNA-gold nanoparticle assemblies
由: Harimech, P, et al.
出版: (2015)

Molecular requirements of high-fidelity replication-competent DNA backbones for orthogonal chemical ligation.
由: Shivalingam, A, et al.
出版: (2017)

Stable end-sealed DNA as robust nano-rulers for in vivo single-molecule fluorescence
由: Plochowietz, A, et al.
出版: (2016)

Enzymatic incorporation and fluorescent labelling of cyclooctyne-modified deoxyuridine triphosphates in DNA.
由: Ren, X, et al.
出版: (2014)

Efficient enzymatic synthesis and dual-colour fluorescent labelling of DNA probes using long chain azido-dUTP and BCN dyes.
由: Ren, X, et al.
出版: (2016)

Squaramide‐based 5’‐phosphate replacements bind to the DNA repair exonuclease SNM1A
由: Dürr, E, et al.
出版: (2018)

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures
由: Manuguerra, I, et al.
出版: (2018)

Structure and dynamics of triazole-linked DNA: biocompatibility explained.
由: Dallmann, A, et al.
出版: (2011)