Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.
<h4>Objective</h4> <p>High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson’s disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between the phase of beta ban...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2016
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| _version_ | 1797090948302241792 |
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| author | van Wijk, B Beudel, M Jha, A Oswal, A Foltynie, T Hariz, M Limousin, P Zrinzo, L Aziz, T Green, A Brown, P Litvak, V |
| author_facet | van Wijk, B Beudel, M Jha, A Oswal, A Foltynie, T Hariz, M Limousin, P Zrinzo, L Aziz, T Green, A Brown, P Litvak, V |
| author_sort | van Wijk, B |
| collection | OXFORD |
| description | <h4>Objective</h4> <p>High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson’s disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between the phase of beta band oscillations and the amplitude of high-frequency oscillations around 300Hz. </p> <h4>Methods</h4> <p>We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean values of spectral power and phase-amplitude coupling with severity of hemibody bradykinesia/rigidity. In addition, we used simultaneously recorded magneto-encephalography to look at functional interactions between the subthalamic nucleus and ipsilateral motor cortex.</p> <h4>Results</h4> <p>We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean values of spectral power and phase-amplitude coupling with severity of hemibody bradykinesia/rigidity. In addition, we used simultaneously recorded magneto-encephalography to look at functional interactions between the subthalamic nucleus and ipsilateral motor cortex.</p> <h4>Conclusions</h4> <p>We speculate that the beta band might impede pro-kinetic high-frequency activity patterns when phase-amplitude coupling is prominent. Furthermore, results provide evidence for a functional subdivision of the beta band into low and high frequencies.</p> <h4>Significance</h4> <p>Our findings contribute to the interpretation of oscillatory activity within the cortico-basal ganglia circuit.</p> |
| first_indexed | 2024-03-07T03:25:59Z |
| format | Journal article |
| id | oxford-uuid:b90cc6ee-89b4-498e-90a0-e7eaca4d64c0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:25:59Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:b90cc6ee-89b4-498e-90a0-e7eaca4d64c02022-03-27T05:00:19ZSubthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b90cc6ee-89b4-498e-90a0-e7eaca4d64c0EnglishSymplectic Elements at OxfordElsevier2016van Wijk, BBeudel, MJha, AOswal, AFoltynie, THariz, MLimousin, PZrinzo, LAziz, TGreen, ABrown, PLitvak, V<h4>Objective</h4> <p>High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson’s disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between the phase of beta band oscillations and the amplitude of high-frequency oscillations around 300Hz. </p> <h4>Methods</h4> <p>We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean values of spectral power and phase-amplitude coupling with severity of hemibody bradykinesia/rigidity. In addition, we used simultaneously recorded magneto-encephalography to look at functional interactions between the subthalamic nucleus and ipsilateral motor cortex.</p> <h4>Results</h4> <p>We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean values of spectral power and phase-amplitude coupling with severity of hemibody bradykinesia/rigidity. In addition, we used simultaneously recorded magneto-encephalography to look at functional interactions between the subthalamic nucleus and ipsilateral motor cortex.</p> <h4>Conclusions</h4> <p>We speculate that the beta band might impede pro-kinetic high-frequency activity patterns when phase-amplitude coupling is prominent. Furthermore, results provide evidence for a functional subdivision of the beta band into low and high frequencies.</p> <h4>Significance</h4> <p>Our findings contribute to the interpretation of oscillatory activity within the cortico-basal ganglia circuit.</p> |
| spellingShingle | van Wijk, B Beudel, M Jha, A Oswal, A Foltynie, T Hariz, M Limousin, P Zrinzo, L Aziz, T Green, A Brown, P Litvak, V Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease. |
| title | Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease. |
| title_full | Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease. |
| title_fullStr | Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease. |
| title_full_unstemmed | Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease. |
| title_short | Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease. |
| title_sort | subthalamic nucleus phase amplitude coupling correlates with motor impairment in parkinson s disease |
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