Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin.
Analysis of molecular interaction fields based on the published crystal structure of thapsigargin bound to the sarco/endoplasmatic reticulum Ca(2+)-ATPase and analysis of the volume and shape of the ligand binding site and of the SERCA-thapsigargin interactions have enabled design of two new compoun...
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Bibliographic Details
| Main Authors: |
Søhoel, H,
Liljefors, T,
Ley, S,
Oliver, S,
Antonello, A,
Smith, M,
Olsen, C,
Isaacs, J,
Christensen, S |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2005
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