Role of adhesion molecules in activation signaling in T lymphocytes.
The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell-cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the...
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1826293177082970112 |
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| author | Dustin, M |
| author_facet | Dustin, M |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell-cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival. |
| first_indexed | 2024-03-07T03:26:05Z |
| format | Journal article |
| id | oxford-uuid:b9147b3f-0b19-44c5-ac50-bfd6f6a0554a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:26:05Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:b9147b3f-0b19-44c5-ac50-bfd6f6a0554a2022-03-27T05:00:27ZRole of adhesion molecules in activation signaling in T lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b9147b3f-0b19-44c5-ac50-bfd6f6a0554aEnglishSymplectic Elements at Oxford2001Dustin, MThe T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell-cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival. |
| spellingShingle | Dustin, M Role of adhesion molecules in activation signaling in T lymphocytes. |
| title | Role of adhesion molecules in activation signaling in T lymphocytes. |
| title_full | Role of adhesion molecules in activation signaling in T lymphocytes. |
| title_fullStr | Role of adhesion molecules in activation signaling in T lymphocytes. |
| title_full_unstemmed | Role of adhesion molecules in activation signaling in T lymphocytes. |
| title_short | Role of adhesion molecules in activation signaling in T lymphocytes. |
| title_sort | role of adhesion molecules in activation signaling in t lymphocytes |
| work_keys_str_mv | AT dustinm roleofadhesionmoleculesinactivationsignalingintlymphocytes |