Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography.
In this study, the upper-limit volume (gas plus partial tissue volume) as well as absolute volume (gas only) of lungs measured with hyperpolarized (3)He-MR imaging is compared with that determined by micro-computed tomography (CT) under similar ventilation conditions in normal rats. Five Brown Norwa...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797090962059558912 |
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| author | Akhavan Sharif, MR Lam, W Ouriadov, A Holdsworth, D Santyr, G |
| author_facet | Akhavan Sharif, MR Lam, W Ouriadov, A Holdsworth, D Santyr, G |
| author_sort | Akhavan Sharif, MR |
| collection | OXFORD |
| description | In this study, the upper-limit volume (gas plus partial tissue volume) as well as absolute volume (gas only) of lungs measured with hyperpolarized (3)He-MR imaging is compared with that determined by micro-computed tomography (CT) under similar ventilation conditions in normal rats. Five Brown Norway rats (210-259 g) were ventilated with O(2), alternately with (3)He, using a computer-controlled ventilator, and 3D density-weighted images of the lungs were acquired during a breath hold after six wash-in breaths of (3)He. The rats were then transferred to a micro-CT scanner, and a similar experimental setup was used to obtain images of the lungs during a breath hold of air with an airway pressure equal to that of the MR imaging breath hold. The upper-limit and absolute volumes obtained from (3)He-MR and micro-CT methods were not significantly different (p > 0.05). The good agreement between the lung volumes measured with the two imaging methods suggests that (3)He-MR imaging can be used for quantitative analysis of lung volume changes in longitudinal studies without the exposure to the ionizing radiation which accompanies micro-CT imaging. |
| first_indexed | 2024-03-07T03:26:12Z |
| format | Journal article |
| id | oxford-uuid:b91da207-b246-4fec-bc4b-ff6f5a236eac |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:26:12Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:b91da207-b246-4fec-bc4b-ff6f5a236eac2022-03-27T05:00:46ZComparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b91da207-b246-4fec-bc4b-ff6f5a236eacEnglishSymplectic Elements at Oxford2010Akhavan Sharif, MRLam, WOuriadov, AHoldsworth, DSantyr, GIn this study, the upper-limit volume (gas plus partial tissue volume) as well as absolute volume (gas only) of lungs measured with hyperpolarized (3)He-MR imaging is compared with that determined by micro-computed tomography (CT) under similar ventilation conditions in normal rats. Five Brown Norway rats (210-259 g) were ventilated with O(2), alternately with (3)He, using a computer-controlled ventilator, and 3D density-weighted images of the lungs were acquired during a breath hold after six wash-in breaths of (3)He. The rats were then transferred to a micro-CT scanner, and a similar experimental setup was used to obtain images of the lungs during a breath hold of air with an airway pressure equal to that of the MR imaging breath hold. The upper-limit and absolute volumes obtained from (3)He-MR and micro-CT methods were not significantly different (p > 0.05). The good agreement between the lung volumes measured with the two imaging methods suggests that (3)He-MR imaging can be used for quantitative analysis of lung volume changes in longitudinal studies without the exposure to the ionizing radiation which accompanies micro-CT imaging. |
| spellingShingle | Akhavan Sharif, MR Lam, W Ouriadov, A Holdsworth, D Santyr, G Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography. |
| title | Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography. |
| title_full | Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography. |
| title_fullStr | Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography. |
| title_full_unstemmed | Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography. |
| title_short | Comparison of hyperpolarized (3)He MRI rat lung volume measurement with micro-computed tomography. |
| title_sort | comparison of hyperpolarized 3 he mri rat lung volume measurement with micro computed tomography |
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