Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease
In Parkinson’s disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson’s pathogenesis. By...
Main Authors: | , , , , , , , , , , , , |
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Format: | Journal article |
Published: |
National Academy of Sciences
2016
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