Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India
<p>Purpose: CKD patients after kidney transplantation continue to suffer from elevated CV events which may be related to low vitamin D and its adverse impact on vascular function. The prevalence of vitamin D deficiency in North Indian kidney transplantation patients and its impact on vascular...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
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Springer Verlag
2018
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| _version_ | 1797090999898472448 |
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| author | Yadav, A Tiwana, S Steel, M Ramachandran, R Kaski, J Jha, V Banerjee, D |
| author_facet | Yadav, A Tiwana, S Steel, M Ramachandran, R Kaski, J Jha, V Banerjee, D |
| author_sort | Yadav, A |
| collection | OXFORD |
| description | <p>Purpose: CKD patients after kidney transplantation continue to suffer from elevated CV events which may be related to low vitamin D and its adverse impact on vascular function. The prevalence of vitamin D deficiency in North Indian kidney transplantation patients and its impact on vascular and bone biomarkers is unknown which this study investigated.</p><p> Methods: Non-diabetic, stable, > 6 months post-kidney transplantation patients, not on vitamin D supplementation, were recruited after informed consent. Data on demographics, anthropometrics and treatment were collected. Blood samples were stored at − 80 °C until analysis for bone and endothelial cell biomarkers using standard ELISA techniques.</p><p> Results: The clinical characteristics were: age 37.4 ± 9.9 years, 80% men, 27% ex-smokers, BP 125.5 ± 15.7/78.6 ± 9.7 mmHg, cholesterol 172.0 ± 47.8 mg/dL, hemoglobin 12.6 ± 2.3 g/dL, calcium 9.5 ± 0.6 mg/d and iPTH 58.4 ± 32.9 ng/mL and vitamin D 36.5 ± 39.8 nmol/L. Patients with vitamin D < 37.5 nmol/L (66%) had similar age, serum creatinine, serum phosphate, iPTH, blood pressure but lower calcium (9.3 ± 0.7 vs. 9.6 ± 0.5 mg/dL; p = 0.024), lower FGF23 (median 18.8 vs. 80.0 pg/mL; p = 0.013) and higher E-selectin (15.8 ± 7.9 vs. 13.0 ± 5.5 ng/mL; p = 0.047). On Univariate analysis, E-selectin (r = − 0.292; p = 0.005), FGF23 (r = 0.217; p = 0.036) and calcium (r = 0.238; p = 0.022) were significantly correlated with vitamin D levels. On stepwise multiple regression analysis, only E-selectin was associated with vitamin D levels (β = − 0.324; p = 0.002).</p><p> Conclusion: Vitamin D deficiency was common in kidney transplant recipients in North India, associated with low FGF23 and high E-selectin. These findings suggest further investigations to assess the role of vitamin D deficiency-associated endothelial dysfunction, its implications and reversibility in kidney transplantation recipients.</p> |
| first_indexed | 2024-03-07T03:26:45Z |
| format | Journal article |
| id | oxford-uuid:b94b224b-beb5-4017-9b8f-cb945ccd3493 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:26:45Z |
| publishDate | 2018 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | oxford-uuid:b94b224b-beb5-4017-9b8f-cb945ccd34932022-03-27T05:02:03ZVitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North IndiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b94b224b-beb5-4017-9b8f-cb945ccd3493Symplectic Elements at OxfordSpringer Verlag2018Yadav, ATiwana, SSteel, MRamachandran, RKaski, JJha, VBanerjee, D<p>Purpose: CKD patients after kidney transplantation continue to suffer from elevated CV events which may be related to low vitamin D and its adverse impact on vascular function. The prevalence of vitamin D deficiency in North Indian kidney transplantation patients and its impact on vascular and bone biomarkers is unknown which this study investigated.</p><p> Methods: Non-diabetic, stable, > 6 months post-kidney transplantation patients, not on vitamin D supplementation, were recruited after informed consent. Data on demographics, anthropometrics and treatment were collected. Blood samples were stored at − 80 °C until analysis for bone and endothelial cell biomarkers using standard ELISA techniques.</p><p> Results: The clinical characteristics were: age 37.4 ± 9.9 years, 80% men, 27% ex-smokers, BP 125.5 ± 15.7/78.6 ± 9.7 mmHg, cholesterol 172.0 ± 47.8 mg/dL, hemoglobin 12.6 ± 2.3 g/dL, calcium 9.5 ± 0.6 mg/d and iPTH 58.4 ± 32.9 ng/mL and vitamin D 36.5 ± 39.8 nmol/L. Patients with vitamin D < 37.5 nmol/L (66%) had similar age, serum creatinine, serum phosphate, iPTH, blood pressure but lower calcium (9.3 ± 0.7 vs. 9.6 ± 0.5 mg/dL; p = 0.024), lower FGF23 (median 18.8 vs. 80.0 pg/mL; p = 0.013) and higher E-selectin (15.8 ± 7.9 vs. 13.0 ± 5.5 ng/mL; p = 0.047). On Univariate analysis, E-selectin (r = − 0.292; p = 0.005), FGF23 (r = 0.217; p = 0.036) and calcium (r = 0.238; p = 0.022) were significantly correlated with vitamin D levels. On stepwise multiple regression analysis, only E-selectin was associated with vitamin D levels (β = − 0.324; p = 0.002).</p><p> Conclusion: Vitamin D deficiency was common in kidney transplant recipients in North India, associated with low FGF23 and high E-selectin. These findings suggest further investigations to assess the role of vitamin D deficiency-associated endothelial dysfunction, its implications and reversibility in kidney transplantation recipients.</p> |
| spellingShingle | Yadav, A Tiwana, S Steel, M Ramachandran, R Kaski, J Jha, V Banerjee, D Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India |
| title | Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India |
| title_full | Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India |
| title_fullStr | Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India |
| title_full_unstemmed | Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India |
| title_short | Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India |
| title_sort | vitamin d deficiency endothelial function and bone biomarkers in post kidney transplantation patients from north india |
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