Upgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size.
The X ray microprobe developed at the Gray Laboratory was originally designed to produce carbon K X rays (278 eV) by electron bombardment and focus them to a few hundred nanometers spot by using a circular diffraction grating with increasing line density (zone plate). The very fine focus achieved (&...
| Główni autorzy: | , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
2002
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| _version_ | 1826293222894206976 |
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| author | Schettino, G Folkard, M Prise, K Vojnovic, B Michael, B |
| author_facet | Schettino, G Folkard, M Prise, K Vojnovic, B Michael, B |
| author_sort | Schettino, G |
| collection | OXFORD |
| description | The X ray microprobe developed at the Gray Laboratory was originally designed to produce carbon K X rays (278 eV) by electron bombardment and focus them to a few hundred nanometers spot by using a circular diffraction grating with increasing line density (zone plate). The very fine focus achieved (< 0.25 micron radius spot) and the highly localised energy deposition of CK X rays (photoelectron range < 7 nm), represent unique tools to investigate modern radiobiological phenomena. Recent improvements have been directed to increase the dose rate (up to approximately 6 Gy.s-1 entrance dose averaged over a typical V79 cell) and to evaluate the possibility of using higher energy photons (AlK of 1.48 keV). The efficiency of the microprobe system has been tested by assessing the clonogenic potential of V79 cells irradiated with CK X ray beams of different sizes (5 and 0.25 microns radius) and investigating the relevance of the spatial distribution of cells for the bystander effect. |
| first_indexed | 2024-03-07T03:26:47Z |
| format | Journal article |
| id | oxford-uuid:b94e17b3-0260-4fc7-9caa-ba6d559d0763 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:26:47Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:b94e17b3-0260-4fc7-9caa-ba6d559d07632022-03-27T05:02:04ZUpgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b94e17b3-0260-4fc7-9caa-ba6d559d0763EnglishSymplectic Elements at Oxford2002Schettino, GFolkard, MPrise, KVojnovic, BMichael, BThe X ray microprobe developed at the Gray Laboratory was originally designed to produce carbon K X rays (278 eV) by electron bombardment and focus them to a few hundred nanometers spot by using a circular diffraction grating with increasing line density (zone plate). The very fine focus achieved (< 0.25 micron radius spot) and the highly localised energy deposition of CK X rays (photoelectron range < 7 nm), represent unique tools to investigate modern radiobiological phenomena. Recent improvements have been directed to increase the dose rate (up to approximately 6 Gy.s-1 entrance dose averaged over a typical V79 cell) and to evaluate the possibility of using higher energy photons (AlK of 1.48 keV). The efficiency of the microprobe system has been tested by assessing the clonogenic potential of V79 cells irradiated with CK X ray beams of different sizes (5 and 0.25 microns radius) and investigating the relevance of the spatial distribution of cells for the bystander effect. |
| spellingShingle | Schettino, G Folkard, M Prise, K Vojnovic, B Michael, B Upgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size. |
| title | Upgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size. |
| title_full | Upgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size. |
| title_fullStr | Upgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size. |
| title_full_unstemmed | Upgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size. |
| title_short | Upgrading of the Gray Laboratory soft X ray microprobe and V79 survival measurements following irradiation of one or all cells with a CK X ray beam of different size. |
| title_sort | upgrading of the gray laboratory soft x ray microprobe and v79 survival measurements following irradiation of one or all cells with a ck x ray beam of different size |
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