Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine
<p style="text-align:justify;">A general route which provides direct access to pyroglutamates from tetramates, making use of Suzuki coupling on an enol mesylate, followed by reduction, is reported. This work permits direct scaffold hopping from tetramate to substituted pyroglutamate...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2019
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| _version_ | 1797091017173762048 |
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| author | Bagum, H Christensen, K Genov, M Pretsch, A Pretsch, D Moloney, M |
| author_facet | Bagum, H Christensen, K Genov, M Pretsch, A Pretsch, D Moloney, M |
| author_sort | Bagum, H |
| collection | OXFORD |
| description | <p style="text-align:justify;">A general route which provides direct access to pyroglutamates from tetramates, making use of Suzuki coupling on an enol mesylate, followed by reduction, is reported. This work permits direct scaffold hopping from tetramate to substituted pyroglutamates. Some compounds in the library showed modest antibacterial activity against Gram-positive bacteria.</p> |
| first_indexed | 2024-03-07T03:27:01Z |
| format | Journal article |
| id | oxford-uuid:b964e511-15eb-4663-98d0-15a70cbd4b70 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:27:01Z |
| publishDate | 2019 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:b964e511-15eb-4663-98d0-15a70cbd4b702022-03-27T05:02:35ZSynthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteineJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b964e511-15eb-4663-98d0-15a70cbd4b70EnglishSymplectic Elements at OxfordAmerican Chemical Society2019Bagum, HChristensen, KGenov, MPretsch, APretsch, DMoloney, M <p style="text-align:justify;">A general route which provides direct access to pyroglutamates from tetramates, making use of Suzuki coupling on an enol mesylate, followed by reduction, is reported. This work permits direct scaffold hopping from tetramate to substituted pyroglutamates. Some compounds in the library showed modest antibacterial activity against Gram-positive bacteria.</p> |
| spellingShingle | Bagum, H Christensen, K Genov, M Pretsch, A Pretsch, D Moloney, M Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine |
| title | Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine |
| title_full | Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine |
| title_fullStr | Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine |
| title_full_unstemmed | Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine |
| title_short | Synthetic access to 3-substituted pyroglutamic acids from tetramate derivatives of serine, threonine, allo-threonine, and cysteine |
| title_sort | synthetic access to 3 substituted pyroglutamic acids from tetramate derivatives of serine threonine allo threonine and cysteine |
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