The need for large-scale randomized evidence.
The reliable detection of moderate differences in major health outcomes that arise as a result of treatment requires large-scale randomized evidence (and the appropriate interpretation of this evidence once it has been generated). This may take the form of a single mega-trial or, exceptionally, a me...
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| Format: | Journal article |
| Language: | English |
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1997
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| _version_ | 1797091017778790400 |
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| author | Baigent, C |
| author_facet | Baigent, C |
| author_sort | Baigent, C |
| collection | OXFORD |
| description | The reliable detection of moderate differences in major health outcomes that arise as a result of treatment requires large-scale randomized evidence (and the appropriate interpretation of this evidence once it has been generated). This may take the form of a single mega-trial or, exceptionally, a meta-analysis of many smaller randomized trials may provide worthwhile information. Small or non-randomized studies cannot generally be trusted to distinguish reliably between a moderate benefit, a moderate hazard, and a negligible difference in major outcomes. Simple design, streamlined data collection, and use of the "uncertainty principle' to guide eligibility would all encourage the recruitment of larger samples in randomized trials. Future trials need to adopt these methods in order to detect any moderate improvements in major outcomes that may await discovery. |
| first_indexed | 2024-03-07T03:27:00Z |
| format | Journal article |
| id | oxford-uuid:b966b7c7-51f4-487a-8379-2ceb966b4588 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:27:00Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:b966b7c7-51f4-487a-8379-2ceb966b45882022-03-27T05:02:34ZThe need for large-scale randomized evidence.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b966b7c7-51f4-487a-8379-2ceb966b4588EnglishSymplectic Elements at Oxford1997Baigent, CThe reliable detection of moderate differences in major health outcomes that arise as a result of treatment requires large-scale randomized evidence (and the appropriate interpretation of this evidence once it has been generated). This may take the form of a single mega-trial or, exceptionally, a meta-analysis of many smaller randomized trials may provide worthwhile information. Small or non-randomized studies cannot generally be trusted to distinguish reliably between a moderate benefit, a moderate hazard, and a negligible difference in major outcomes. Simple design, streamlined data collection, and use of the "uncertainty principle' to guide eligibility would all encourage the recruitment of larger samples in randomized trials. Future trials need to adopt these methods in order to detect any moderate improvements in major outcomes that may await discovery. |
| spellingShingle | Baigent, C The need for large-scale randomized evidence. |
| title | The need for large-scale randomized evidence. |
| title_full | The need for large-scale randomized evidence. |
| title_fullStr | The need for large-scale randomized evidence. |
| title_full_unstemmed | The need for large-scale randomized evidence. |
| title_short | The need for large-scale randomized evidence. |
| title_sort | need for large scale randomized evidence |
| work_keys_str_mv | AT baigentc theneedforlargescalerandomizedevidence AT baigentc needforlargescalerandomizedevidence |