Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.

Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.

AIMS/HYPOTHESIS: The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions. Additionally, the coding non-synon...

Bibliografiset tiedot
Päätekijät:	Zeggini, E, Groves, C, Parkinson, JR, Halford, S, Owen, K, Frayling, T, Walker, M, Hitman, G, Levy, J, O'Rahilly, S, Hattersley, A, McCarthy, M
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2005

Samankaltaisia teoksia

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
Tekijä: Owen, K, et al.
Julkaistu: (2006)

Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes
Tekijä: Boraska, V, et al.
Julkaistu: (2010)

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
Tekijä: Liew, C, et al.
Julkaistu: (2004)

A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults
Tekijä: Randall, L, et al.
Julkaistu: (2010)

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
Tekijä: Groves, C, et al.
Julkaistu: (2003)

Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs
Tekijä: Groves, C, et al.
Julkaistu: (2002)

Susceptibility for latent autoimmune diabetes in adults (LADA) is determined by variation at the 1DDM2 (insulin-gene) locus in white Caucasian patients from UK repositories
Tekijä: Desai, M, et al.
Julkaistu: (2005)

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
Tekijä: Desai, M, et al.
Julkaistu: (2006)

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
Tekijä: Frayling, T, et al.
Julkaistu: (2000)

LTA-TNF HAPLOTYPE STUDIES IDENTIFY ADDITIONAL RHEUMATOID ARTHRITIS SUSCEPTIBILITY REGIONS IN THE MHC
Tekijä: Newton, J, et al.
Julkaistu: (2002)

The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.
Tekijä: Tobin, D, et al.
Julkaistu: (2010)

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
Tekijä: Groves, C, et al.
Julkaistu: (2006)

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
Tekijä: Zeggini, E, et al.
Julkaistu: (2005)

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
Tekijä: Wiltshire, S, et al.
Julkaistu: (2002)

Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
Tekijä: Zeggini, E, et al.
Julkaistu: (2004)

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
Tekijä: Zeggini, E, et al.
Julkaistu: (2004)

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
Tekijä: Huxtable, S, et al.
Julkaistu: (2000)

Linkage analysis in the Diabetes (UK) Warren 2 sibpair repository supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-24.
Tekijä: McCarthy, M, et al.
Julkaistu: (2001)

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
Tekijä: Patel, S, et al.
Julkaistu: (2006)

Type 2 diabetes and the human homolog of the rat insulin resistance gene, CD36: No linkage or association in Europeans
Tekijä: McCarthy, M, et al.
Julkaistu: (1999)

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
Tekijä: Wiltshire, S, et al.
Julkaistu: (2004)

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
Tekijä: Groves, C, et al.
Julkaistu: (2006)

Susceptibility effects of variation at the IDDM2 (Insulin-gene) locus in latent autoimmune diabetes in adults (LADA).
Tekijä: Desai, M, et al.
Julkaistu: (2003)

The BDA Warren Type 2 Diabetes Sibpair Repository: Susceptibility regions identified by genome scan of 439 European families
Tekijä: McCarthy, M, et al.
Julkaistu: (2000)

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Tekijä: Weedon, M, et al.
Julkaistu: (2005)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
Tekijä: Weedon, M, et al.
Julkaistu: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
Tekijä: Weedon, M, et al.
Julkaistu: (2006)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes
Tekijä: Jafar-Mohammadi, B, et al.
Julkaistu: (2009)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.
Tekijä: Jafar-Mohammadi, B, et al.
Julkaistu: (2009)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
Tekijä: Freathy, R, et al.
Julkaistu: (2006)

Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis.
Tekijä: Bowes, J, et al.
Julkaistu: (2010)

Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis
Tekijä: Bowes, J, et al.
Julkaistu: (2010)

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
Tekijä: Frayling, T, et al.
Julkaistu: (2003)

Role of low frequency variants in HNF1A exons 8-10 encoding hepatocyte nuclear factor-1 alpha isoform A to susceptibility to Type 2 diabetes
Tekijä: Jafar-Mohammadi, B, et al.
Julkaistu: (2010)

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.
Tekijä: Wiltshire, S, et al.
Julkaistu: (2001)

Extended analysis of genome-wide scans provides clues about novel common and rare susceptibility loci for type 2 diabetes
Tekijä: Zeggini, E, et al.
Julkaistu: (2008)

Identifying susceptibility variants for type 2 diabetes.
Tekijä: Zeggini, E, et al.
Julkaistu: (2007)

Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.
Tekijä: Wiltshire, S, et al.
Julkaistu: (2006)

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
Tekijä: Owen, K, et al.
Julkaistu: (2004)

Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
Tekijä: Bell, C, et al.
Julkaistu: (2010)