Oxidation of p-aminophenols and formal radical cyclization onto benzene rings: formation of benzo-fused nitrogen heterocycles.

p-Iodophenol and its O-MOM-protected ether can be converted into iodoamines 2. These give cross-conjugated ketones 3 on oxidation with hypervalent iodides in the presence of methanol, and the ketones undergo radical cyclization. Exposure of the products to acid or sequential treatment with a Grignar...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Fletcher, S, Clive, D, Peng, J, Wingert, D
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2005