Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
<p><b>Background</b></p> COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2024
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| _version_ | 1824458924375408640 |
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| author | Citarella, BW Kartsonaki, C Ibáñez-Prada, ED Gonçalves, BP Baruch, J Escher, M Pritchard, MG Wei, J Philippy, F Dagens, A Hall, M Lee, J Kutsogiannis, DJ Wils, E-J Fernandes, MA Tirupakuzhi Vijayaraghavan, BK Panda, PK Martin-Loeches, I Ohshimo, S Fatoni, AZ Horby, P Dunning, J Rello, J Merson, L Rojek, A Vaillant, M Olliaro, P Reyes, LF ISARIC Clinical Characterisation Group |
| author_facet | Citarella, BW Kartsonaki, C Ibáñez-Prada, ED Gonçalves, BP Baruch, J Escher, M Pritchard, MG Wei, J Philippy, F Dagens, A Hall, M Lee, J Kutsogiannis, DJ Wils, E-J Fernandes, MA Tirupakuzhi Vijayaraghavan, BK Panda, PK Martin-Loeches, I Ohshimo, S Fatoni, AZ Horby, P Dunning, J Rello, J Merson, L Rojek, A Vaillant, M Olliaro, P Reyes, LF ISARIC Clinical Characterisation Group |
| author_sort | Citarella, BW |
| collection | OXFORD |
| description | <p><b>Background</b></p>
COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission.
<p><b>Methods</b></p>
This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not.
<p><b>Results</b></p>
Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]).
<p><b>Conclusion</b></p>
Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders. |
| first_indexed | 2025-02-19T04:33:37Z |
| format | Journal article |
| id | oxford-uuid:b991eb53-c28b-4985-9473-7dc176adbeef |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:33:37Z |
| publishDate | 2024 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:b991eb53-c28b-4985-9473-7dc176adbeef2025-01-20T13:16:56ZCharacteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptomsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b991eb53-c28b-4985-9473-7dc176adbeefEnglishSymplectic ElementsCell Press2024Citarella, BWKartsonaki, CIbáñez-Prada, EDGonçalves, BPBaruch, JEscher, MPritchard, MGWei, JPhilippy, FDagens, AHall, MLee, JKutsogiannis, DJWils, E-JFernandes, MATirupakuzhi Vijayaraghavan, BKPanda, PKMartin-Loeches, IOhshimo, SFatoni, AZHorby, PDunning, JRello, JMerson, LRojek, AVaillant, MOlliaro, PReyes, LFISARIC Clinical Characterisation Group<p><b>Background</b></p> COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. <p><b>Methods</b></p> This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. <p><b>Results</b></p> Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]). <p><b>Conclusion</b></p> Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders. |
| spellingShingle | Citarella, BW Kartsonaki, C Ibáñez-Prada, ED Gonçalves, BP Baruch, J Escher, M Pritchard, MG Wei, J Philippy, F Dagens, A Hall, M Lee, J Kutsogiannis, DJ Wils, E-J Fernandes, MA Tirupakuzhi Vijayaraghavan, BK Panda, PK Martin-Loeches, I Ohshimo, S Fatoni, AZ Horby, P Dunning, J Rello, J Merson, L Rojek, A Vaillant, M Olliaro, P Reyes, LF ISARIC Clinical Characterisation Group Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms |
| title | Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms |
| title_full | Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms |
| title_fullStr | Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms |
| title_full_unstemmed | Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms |
| title_short | Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms |
| title_sort | characteristics and outcomes of covid 19 patients admitted to hospital with and without respiratory symptoms |
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