Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study

<p><strong>Background</strong></p> There is limited prospective evidence on the association between meat consumption and many common, non-cancerous health outcomes. We examined associations of meat intake with risk of 25 common conditions (other than cancer). <p><s...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Papier, K, Fensom, GK, Knuppel, A, Appleby, PN, Tong, TYN, Schmidt, JA, Travis, RC, Key, TJ, Perez-Cornago, A
Materialtyp: Journal article
Språk:English
Publicerad: BioMed Central 2021
_version_ 1826293270177644544
author Papier, K
Fensom, GK
Knuppel, A
Appleby, PN
Tong, TYN
Schmidt, JA
Travis, RC
Key, TJ
Perez-Cornago, A
author_facet Papier, K
Fensom, GK
Knuppel, A
Appleby, PN
Tong, TYN
Schmidt, JA
Travis, RC
Key, TJ
Perez-Cornago, A
author_sort Papier, K
collection OXFORD
description <p><strong>Background</strong></p> There is limited prospective evidence on the association between meat consumption and many common, non-cancerous health outcomes. We examined associations of meat intake with risk of 25 common conditions (other than cancer). <p><strong>Methods</strong></p> We used data from 474,985 middle-aged adults recruited into the UK Biobank study between 2006 and 2010 and followed up until 2017 (mean follow-up 8.0 years) with available information on meat intake at baseline (collected via touchscreen questionnaire), and linked hospital admissions and mortality data. For a large sub-sample (~ 69,000), dietary intakes were re-measured three or more times using an online, 24-h recall questionnaire. <p><strong>Results</strong></p> On average, participants who reported consuming meat regularly (three or more times per week) had more adverse health behaviours and characteristics than participants who consumed meat less regularly, and most of the positive associations observed for meat consumption and health risks were substantially attenuated after adjustment for body mass index (BMI). In multi-variable adjusted (including BMI) Cox regression models corrected for multiple testing, higher consumption of unprocessed red and processed meat combined was associated with higher risks of ischaemic heart disease (hazard ratio (HRs) per 70 g/day higher intake 1.15, 95% confidence intervals (CIs) 1.07–1.23), pneumonia (1.31, 1.18–1.44), diverticular disease (1.19, 1.11–1.28), colon polyps (1.10, 1.06–1.15), and diabetes (1.30, 1.20–1.42); results were similar for unprocessed red meat and processed meat intakes separately. Higher consumption of unprocessed red meat alone was associated with a lower risk of iron deficiency anaemia (IDA: HR per 50 g/day higher intake 0.80, 95% CIs 0.72–0.90). Higher poultry meat intake was associated with higher risks of gastro-oesophageal reflux disease (HR per 30 g/day higher intake 1.17, 95% CIs 1.09–1.26), gastritis and duodenitis (1.12, 1.05–1.18), diverticular disease (1.10, 1.04–1.17), gallbladder disease (1.11, 1.04–1.19), and diabetes (1.14, 1.07–1.21), and a lower IDA risk (0.83, 0.76–0.90). <p><strong>Conclusions</strong></p> Higher unprocessed red meat, processed meat, and poultry meat consumption was associated with higher risks of several common conditions; higher BMI accounted for a substantial proportion of these increased risks suggesting that residual confounding or mediation by adiposity might account for some of these remaining associations. Higher unprocessed red meat and poultry meat consumption was associated with lower IDA risk.
first_indexed 2024-03-07T03:27:31Z
format Journal article
id oxford-uuid:b993f4b8-6f5d-49fe-ab8c-d6f90e03dd39
institution University of Oxford
language English
last_indexed 2024-03-07T03:27:31Z
publishDate 2021
publisher BioMed Central
record_format dspace
spelling oxford-uuid:b993f4b8-6f5d-49fe-ab8c-d6f90e03dd392022-03-27T05:03:50ZMeat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b993f4b8-6f5d-49fe-ab8c-d6f90e03dd39EnglishSymplectic ElementsBioMed Central2021Papier, KFensom, GKKnuppel, AAppleby, PNTong, TYNSchmidt, JATravis, RCKey, TJPerez-Cornago, A<p><strong>Background</strong></p> There is limited prospective evidence on the association between meat consumption and many common, non-cancerous health outcomes. We examined associations of meat intake with risk of 25 common conditions (other than cancer). <p><strong>Methods</strong></p> We used data from 474,985 middle-aged adults recruited into the UK Biobank study between 2006 and 2010 and followed up until 2017 (mean follow-up 8.0 years) with available information on meat intake at baseline (collected via touchscreen questionnaire), and linked hospital admissions and mortality data. For a large sub-sample (~ 69,000), dietary intakes were re-measured three or more times using an online, 24-h recall questionnaire. <p><strong>Results</strong></p> On average, participants who reported consuming meat regularly (three or more times per week) had more adverse health behaviours and characteristics than participants who consumed meat less regularly, and most of the positive associations observed for meat consumption and health risks were substantially attenuated after adjustment for body mass index (BMI). In multi-variable adjusted (including BMI) Cox regression models corrected for multiple testing, higher consumption of unprocessed red and processed meat combined was associated with higher risks of ischaemic heart disease (hazard ratio (HRs) per 70 g/day higher intake 1.15, 95% confidence intervals (CIs) 1.07–1.23), pneumonia (1.31, 1.18–1.44), diverticular disease (1.19, 1.11–1.28), colon polyps (1.10, 1.06–1.15), and diabetes (1.30, 1.20–1.42); results were similar for unprocessed red meat and processed meat intakes separately. Higher consumption of unprocessed red meat alone was associated with a lower risk of iron deficiency anaemia (IDA: HR per 50 g/day higher intake 0.80, 95% CIs 0.72–0.90). Higher poultry meat intake was associated with higher risks of gastro-oesophageal reflux disease (HR per 30 g/day higher intake 1.17, 95% CIs 1.09–1.26), gastritis and duodenitis (1.12, 1.05–1.18), diverticular disease (1.10, 1.04–1.17), gallbladder disease (1.11, 1.04–1.19), and diabetes (1.14, 1.07–1.21), and a lower IDA risk (0.83, 0.76–0.90). <p><strong>Conclusions</strong></p> Higher unprocessed red meat, processed meat, and poultry meat consumption was associated with higher risks of several common conditions; higher BMI accounted for a substantial proportion of these increased risks suggesting that residual confounding or mediation by adiposity might account for some of these remaining associations. Higher unprocessed red meat and poultry meat consumption was associated with lower IDA risk.
spellingShingle Papier, K
Fensom, GK
Knuppel, A
Appleby, PN
Tong, TYN
Schmidt, JA
Travis, RC
Key, TJ
Perez-Cornago, A
Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study
title Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study
title_full Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study
title_fullStr Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study
title_full_unstemmed Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study
title_short Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study
title_sort meat consumption and risk of 25 common conditions outcome wide analyses in 475 000 men and women in the uk biobank study
work_keys_str_mv AT papierk meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy
AT fensomgk meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy
AT knuppela meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy
AT applebypn meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy
AT tongtyn meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy
AT schmidtja meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy
AT travisrc meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy
AT keytj meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy
AT perezcornagoa meatconsumptionandriskof25commonconditionsoutcomewideanalysesin475000menandwomenintheukbiobankstudy