Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing.
BACKGROUND: Children exposed to tobacco smoke early in life have a higher risk of wheeze. Individual susceptibility may depend on genetic factors. OBJECTIVE: We studied whether variations in single nucleotide polymorphisms (SNPs) in the TNF, glutathione S transferase P1 (GSTP1) and beta2-adrenorecep...
| Main Authors: | , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2010
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| _version_ | 1826293280384483328 |
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| author | Panasevich, S Lindgren, C Kere, J Wickman, M Pershagen, G Nyberg, F Melén, E |
| author_facet | Panasevich, S Lindgren, C Kere, J Wickman, M Pershagen, G Nyberg, F Melén, E |
| author_sort | Panasevich, S |
| collection | OXFORD |
| description | BACKGROUND: Children exposed to tobacco smoke early in life have a higher risk of wheeze. Individual susceptibility may depend on genetic factors. OBJECTIVE: We studied whether variations in single nucleotide polymorphisms (SNPs) in the TNF, glutathione S transferase P1 (GSTP1) and beta2-adrenoreceptor (ADRB2) genes modify the effect of early maternal smoking on the development of childhood asthma, wheeze and allergic sensitization. METHODS: In the Swedish prospective birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiological Survey) (n=4089), data collection included questionnaires to measure tobacco smoke exposure and clinical outcomes up to age 4 and medical examinations with blood sampling for specific IgE measurements and genotyping. We defined early maternal smoking as daily smoking by the mother during pregnancy and/or postnatally. We investigated five TNF, six GSTP1 and three ADRB2 SNPs in 982 selected wheezers and non-wheezers. RESULTS: An interaction with early maternal smoking was found for three TNF SNPs (-857C/T, Intron 1, Intron 3) with respect to early wheeze (up to 2 years of age). For example, the odds ratio (OR) for developing early wheeze related to early maternal smoking was 2.4 [95% confidence interval (CI) 1.6-3.7] in children with a wild-type CC homozygote genotype of the TNF-857 SNP, while no tobacco-related risk was seen in children carrying the rare T allele. A clear dose response was observed in children with the CC genotype, with an OR of 1.3 (95% CI 1.1-1.5) per each additional pack per week smoked by the mother during pregnancy. A suggestive interaction with early maternal smoking was also seen for three GSTP1 SNPs (Intron 5, Intron 6 and Ile105Val) with respect to transient wheeze, but not for ADRB2 and wheeze phenotypes. No effect modifications were observed for allergic sensitization. CONCLUSION: Our results suggest that the risk of early childhood wheeze associated with early maternal smoking may be modified by TNF and GSTP1 polymorphisms. |
| first_indexed | 2024-03-07T03:27:41Z |
| format | Journal article |
| id | oxford-uuid:b99f681f-71d4-44b1-ac5f-fdd4d1147e4d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:27:41Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:b99f681f-71d4-44b1-ac5f-fdd4d1147e4d2022-03-27T05:04:08ZInteraction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b99f681f-71d4-44b1-ac5f-fdd4d1147e4dEnglishSymplectic Elements at Oxford2010Panasevich, SLindgren, CKere, JWickman, MPershagen, GNyberg, FMelén, EBACKGROUND: Children exposed to tobacco smoke early in life have a higher risk of wheeze. Individual susceptibility may depend on genetic factors. OBJECTIVE: We studied whether variations in single nucleotide polymorphisms (SNPs) in the TNF, glutathione S transferase P1 (GSTP1) and beta2-adrenoreceptor (ADRB2) genes modify the effect of early maternal smoking on the development of childhood asthma, wheeze and allergic sensitization. METHODS: In the Swedish prospective birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiological Survey) (n=4089), data collection included questionnaires to measure tobacco smoke exposure and clinical outcomes up to age 4 and medical examinations with blood sampling for specific IgE measurements and genotyping. We defined early maternal smoking as daily smoking by the mother during pregnancy and/or postnatally. We investigated five TNF, six GSTP1 and three ADRB2 SNPs in 982 selected wheezers and non-wheezers. RESULTS: An interaction with early maternal smoking was found for three TNF SNPs (-857C/T, Intron 1, Intron 3) with respect to early wheeze (up to 2 years of age). For example, the odds ratio (OR) for developing early wheeze related to early maternal smoking was 2.4 [95% confidence interval (CI) 1.6-3.7] in children with a wild-type CC homozygote genotype of the TNF-857 SNP, while no tobacco-related risk was seen in children carrying the rare T allele. A clear dose response was observed in children with the CC genotype, with an OR of 1.3 (95% CI 1.1-1.5) per each additional pack per week smoked by the mother during pregnancy. A suggestive interaction with early maternal smoking was also seen for three GSTP1 SNPs (Intron 5, Intron 6 and Ile105Val) with respect to transient wheeze, but not for ADRB2 and wheeze phenotypes. No effect modifications were observed for allergic sensitization. CONCLUSION: Our results suggest that the risk of early childhood wheeze associated with early maternal smoking may be modified by TNF and GSTP1 polymorphisms. |
| spellingShingle | Panasevich, S Lindgren, C Kere, J Wickman, M Pershagen, G Nyberg, F Melén, E Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. |
| title | Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. |
| title_full | Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. |
| title_fullStr | Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. |
| title_full_unstemmed | Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. |
| title_short | Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing. |
| title_sort | interaction between early maternal smoking and variants in tnf and gstp1 in childhood wheezing |
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