SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops

A recent Nature paper by Xu et al describes an important link between RNA polymerase II promoterproximal pausing and genome stability maintenance orchestrated by liquid droplet formation to reduce unwanted R-loop accumulation.

Dettagli Bibliografici
Autore principale:	Gromak, N
Natura:	Journal article
Lingua:	English
Pubblicazione:	Cell Press 2023

Documenti analoghi

Senataxin: genome guardian at the interface of transcription and neurodegeneration
di: Groh, M, et al.
Pubblicazione: (2016)

R-loop immunoprecipitation: a method to detect R-loop interacting factors
di: Beghè, C, et al.
Pubblicazione: (2022)

An implementation of LoSS detection using SOSS model
di: Rohani, M.F, et al.
Pubblicazione: (2007)

R-loops promote antisense transcription across the mammalian genome
di: Tan-Wong, SM, et al.
Pubblicazione: (2019)

Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops
di: Ma, TS, et al.
Pubblicazione: (2023)

Out of balance: R-loops in human disease
di: Groh, M, et al.
Pubblicazione: (2014)

Metabolic gatekeeper function of B-lymphoid transcription factors
di: Chan, LN, et al.
Pubblicazione: (2017)

APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
di: McCann, JL, et al.
Pubblicazione: (2023)

Green gatekeepers
di: Enriques, L, et al.
Pubblicazione: (2024)

RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage
di: Cristini, A, et al.
Pubblicazione: (2018)

The influence of gatekeepers on project performance in a major R&D facility
di: Katz, Ralph., et al.
Pubblicazione: (2009)

Edited GluR2, a gatekeeper for motor neurone survival?
di: Buckingham, S, et al.
Pubblicazione: (2008)

Health Service Gatekeepers.
di: Malcomson, J
Pubblicazione: (2003)

Health service gatekeepers
di: Malcomson, J
Pubblicazione: (2003)

Health Service Gatekeepers.
di: Malcomson, J
Pubblicazione: (2004)

Health Service Gatekeepers.
di: Malcomson, J
Pubblicazione: (2003)

Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks
di: Cristini, A, et al.
Pubblicazione: (2019)

Gatekeepers : the professions and corporate governance /
di: Coffee, John C., 1944-
Pubblicazione: (2006)

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
di: Cristini, A, et al.
Pubblicazione: (2022)

Gatekeeping girls’ access to education: an exploration of matrilineal relationships, gatekeepers, and contentions at the micro-household-level
di: Akuffo, AG
Pubblicazione: (2024)

R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus.
di: Sun, Q, et al.
Pubblicazione: (2013)

Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks
di: Long, Q, et al.
Pubblicazione: (2024)

R-loopDB: a database for R-loop forming sequences (RLFS) and R-loops
di: Jenjaroenpun, Piroon, et al.
Pubblicazione: (2017)

An investigation into the managerial roles and career paths of gatekeepers and project supervisors in a major R&D facility
di: Katz, Ralph., et al.
Pubblicazione: (2009)

Role of R-loops in pause-dependent transcriptional termination of RNA polymerase II
di: Skourti-Stathaki, K
Pubblicazione: (2012)

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome
di: Groh, M, et al.
Pubblicazione: (2014)

CD45 functions as a signaling gatekeeper in T cells
di: Courtney, Adam H, et al.
Pubblicazione: (2021)

"Gatekeeper or crisis manager? Coverage of "Lahad Datu" conflict"
di: Ambikapathy, Manimegalai, et al.
Pubblicazione: (2018)

Gatekeepers Liability for Internet Intermediaries in Malaysia: Way Forward
di: Ida Shafinaz Mohamed Kamil, et al.
Pubblicazione: (2020)

Technology transfer to developing countries; the international technological gatekeeper
di: Allen, Thomas J., et al.
Pubblicazione: (2009)

External communication and project performance : an investigation into the role of gatekeepers
di: Katz, Ralph., et al.
Pubblicazione: (2009)

Technology transfer to developing countries: the international technological gatekeeper
di: Allen, Thomas J., et al.
Pubblicazione: (2009)

Epithelial cell polarity: a major gatekeeper against cancer?
di: Royer, C, et al.
Pubblicazione: (2011)

Epithelial cell polarity: A major gatekeeper against cancer
di: Royer, C, et al.
Pubblicazione: (2011)

Gatekeeping influences and journalistic capital : proposing a mechanism of influence
di: Tandoc, Edson C., Jr.
Pubblicazione: (2020)

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
di: West, S, et al.
Pubblicazione: (2004)

Gene loops enhance transcriptional directionality
di: Tan-Wong, S, et al.
Pubblicazione: (2012)

Exon tethering in transcription by RNA polymerase II.
di: Dye, M, et al.
Pubblicazione: (2006)

Corporate governance: Nominee director the gatekeeper / Yang Chik Adam
di: Adam, Yang Chik
Pubblicazione: (2015)

Agentic neglect: teachers as gatekeepers of England's national computing curriculum
di: Larke, L
Pubblicazione: (2019)