SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops

A recent Nature paper by Xu et al describes an important link between RNA polymerase II promoterproximal pausing and genome stability maintenance orchestrated by liquid droplet formation to reduce unwanted R-loop accumulation.

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Gromak, N
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Cell Press 2023

Míreanna comhchosúla

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Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions
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RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability
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R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus.
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JWST-TST DREAMS: A Supersolar Metallicity in WASP-17 b’s Dayside Atmosphere from NIRISS SOSS Eclipse Spectroscopy
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R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome
de réir: Groh, M, et al.
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