SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops

A recent Nature paper by Xu et al describes an important link between RNA polymerase II promoterproximal pausing and genome stability maintenance orchestrated by liquid droplet formation to reduce unwanted R-loop accumulation.

Библиографические подробности
Главный автор:	Gromak, N
Формат:	Journal article
Язык:	English
Опубликовано:	Cell Press 2023

Схожие документы

Mechanisms of SOSS‐Integrator–PP2A complex in attenuating R‐loops and promoting genome stability
по: Jingwen Wang, и др.
Опубликовано: (2024-01-01)

Senataxin: genome guardian at the interface of transcription and neurodegeneration
по: Groh, M, и др.
Опубликовано: (2016)

R-loop immunoprecipitation: a method to detect R-loop interacting factors
по: Beghè, C, и др.
Опубликовано: (2022)

An implementation of LoSS detection using SOSS model
по: Rohani, M.F, и др.
Опубликовано: (2007)

Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops
по: Ma, TS, и др.
Опубликовано: (2023)

Out of balance: R-loops in human disease
по: Groh, M, и др.
Опубликовано: (2014)

PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity
по: Sundarraj Jayakumar, и др.
Опубликовано: (2024-01-01)

R-loops promote antisense transcription across the mammalian genome
по: Tan-Wong, SM, и др.
Опубликовано: (2019)

Evaluation of dynamic corneal response parameters and the biomechanical E-staging after Intacs® SK implantation in keratoconus
по: Elias Flockerzi, и др.
Опубликовано: (2024-04-01)

APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
по: McCann, JL, и др.
Опубликовано: (2023)

RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage
по: Cristini, A, и др.
Опубликовано: (2018)

Metabolic gatekeeper function of B-lymphoid transcription factors
по: Chan, LN, и др.
Опубликовано: (2017)

Author Correction: PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity
по: Sundarraj Jayakumar, и др.
Опубликовано: (2024-06-01)

A new gatekeeper to control oligodendrogenesis.
по: Tim Czopka
Опубликовано: (2024-07-01)

Who Am I? Psychometric properties of the persian version of the sense of self scale (SOSS)
по: Golnaz Mazaheri Nejad Fard, и др.
Опубликовано: (2024-12-01)

Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks
по: Cristini, A, и др.
Опубликовано: (2019)

Green gatekeepers
по: Enriques, L, и др.
Опубликовано: (2024)

Gatekeeping Science
по: Jan Thohauge Frederiksen, и др.
Опубликовано: (2025-01-01)

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
по: Cristini, A, и др.
Опубликовано: (2022)

Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions
по: Kiwon Park, и др.
Опубликовано: (2024-12-01)

RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability
по: Manisha Jalan, и др.
Опубликовано: (2024-09-01)

The influence of gatekeepers on project performance in a major R&D facility
по: Katz, Ralph., и др.
Опубликовано: (2009)

Edited GluR2, a gatekeeper for motor neurone survival?
по: Buckingham, S, и др.
Опубликовано: (2008)

Health Service Gatekeepers.
по: Malcomson, J
Опубликовано: (2003)

Health service gatekeepers
по: Malcomson, J
Опубликовано: (2003)

Health Service Gatekeepers.
по: Malcomson, J
Опубликовано: (2004)

Health Service Gatekeepers.
по: Malcomson, J
Опубликовано: (2003)

Gatekeeping at BiO
по: Daniel A. Gorelick
Опубликовано: (2023-12-01)

Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks
по: Long, Q, и др.
Опубликовано: (2024)

Who Keeps the Gate? Digital Gatekeeping in New Media
по: Karolina Pałka-Suchojad
Опубликовано: (2021-06-01)

Gatekeepers : the professions and corporate governance /
по: Coffee, John C., 1944-
Опубликовано: (2006)

On Gatekeepers and Structural Competition Problems
по: Christian Rusche, и др.
Опубликовано: (2021-08-01)

Os gatekeepers na engenharia
по: Jeannette M. Kremer
Опубликовано: (1981-06-01)

Traducción y validez de la Stigma of Suicide Scale Short Form (SOSS-SF) en población peruana
по: Jonatan Baños-Chaparro, и др.
Опубликовано: (2023-05-01)

R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus.
по: Sun, Q, и др.
Опубликовано: (2013)

Gatekeeping girls’ access to education: an exploration of matrilineal relationships, gatekeepers, and contentions at the micro-household-level
по: Akuffo, AG
Опубликовано: (2024)

Post-publication gatekeeping practices: Exploring conversational and visual gatekeeping on Finnish newspapers’ Instagram accounts
по: Salonen Margareta, и др.
Опубликовано: (2023-09-01)

JWST-TST DREAMS: A Supersolar Metallicity in WASP-17 b’s Dayside Atmosphere from NIRISS SOSS Eclipse Spectroscopy
по: Amélie Gressier, и др.
Опубликовано: (2025-01-01)

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome
по: Groh, M, и др.
Опубликовано: (2014)

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
по: West, S, и др.
Опубликовано: (2004)