Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent, r...

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Huvudupphovsmän: Kolz, M, Johnson, T, Sanna, S, Teumer, A, Vitart, V, Perola, M, Mangino, M, Albrecht, E, Wallace, C, Farrall, M, Johansson, A, Nyholt, DR, Aulchenko, Y, Beckmann, J, Bergmann, S, Bochud, M, Brown, M, Campbell, H, Connell, J, Dominiczak, A, Homuth, G, Lamina, C, McCarthy, M, Meitinger, T, Mooser, V, Munroe, P, Nauck, M, Peden, J, Prokisch, H, Salo, P, Salomaa, V, Samani, N, Schlessinger, D, Uda, M, Volker, U, Waeber, G, Waterworth, D, Wang-Sattler, R, Wright, A, Adamski, J, Whitfield, J, Gyllensten, U, Wilson, J, Rudan, I, Pramstaller, P, Watkins, H, Doering, A, Wichmann, H, Spector, T, Peltonen, L, Volzke, H, Nagaraja, R, Vollenweider, P, Caulfield, M, Illig, T, Gieger, C
Materialtyp: Journal article
Språk:English
Publicerad: Public Library of Science 2009

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