Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs.
Ultrastructural changes to P. falciparum-infected red blood cells were examined in vitro after treatment with antimalarial drugs. Artesunate had the most rapid parasitocidal effect. All three drugs caused structural changes within the parasite, including dilatation of the parasitophorus vacuole memb...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1797091088225271808 |
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| author | Sachanonta, N Chotivanich, K Chaisri, U Turner, G Ferguson, D Day, N Pongponratn, E |
| author_facet | Sachanonta, N Chotivanich, K Chaisri, U Turner, G Ferguson, D Day, N Pongponratn, E |
| author_sort | Sachanonta, N |
| collection | OXFORD |
| description | Ultrastructural changes to P. falciparum-infected red blood cells were examined in vitro after treatment with antimalarial drugs. Artesunate had the most rapid parasitocidal effect. All three drugs caused structural changes within the parasite, including dilatation of the parasitophorus vacuole membrane, depletion of ribosomes, mitochondrial swelling, and decreased formation of hemozoin crystals. The structure of surface knobs and Maurer's clefts were similar to controls but reduced in number. Only depletion of free ribosomes correlated with antimalarial drug exposure. Drug treatment decreased movement of hemozoin granules within parasites on real-time microscopy, before recognizable morphological changes of parasite death. |
| first_indexed | 2024-03-07T03:28:03Z |
| format | Journal article |
| id | oxford-uuid:b9bb79ce-fc31-4870-9a21-ff4ab4fc42e5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:28:03Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:b9bb79ce-fc31-4870-9a21-ff4ab4fc42e52022-03-27T05:04:58ZUltrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b9bb79ce-fc31-4870-9a21-ff4ab4fc42e5EnglishSymplectic Elements at Oxford2011Sachanonta, NChotivanich, KChaisri, UTurner, GFerguson, DDay, NPongponratn, EUltrastructural changes to P. falciparum-infected red blood cells were examined in vitro after treatment with antimalarial drugs. Artesunate had the most rapid parasitocidal effect. All three drugs caused structural changes within the parasite, including dilatation of the parasitophorus vacuole membrane, depletion of ribosomes, mitochondrial swelling, and decreased formation of hemozoin crystals. The structure of surface knobs and Maurer's clefts were similar to controls but reduced in number. Only depletion of free ribosomes correlated with antimalarial drug exposure. Drug treatment decreased movement of hemozoin granules within parasites on real-time microscopy, before recognizable morphological changes of parasite death. |
| spellingShingle | Sachanonta, N Chotivanich, K Chaisri, U Turner, G Ferguson, D Day, N Pongponratn, E Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs. |
| title | Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs. |
| title_full | Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs. |
| title_fullStr | Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs. |
| title_full_unstemmed | Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs. |
| title_short | Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs. |
| title_sort | ultrastructural and real time microscopic changes in p falciparum infected red blood cells following treatment with antimalarial drugs |
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