Binding of tetracycline to its aptamer determined by 2D-correlated Mn2+ hyperfine spectroscopy

Binding of tetracycline to its aptamer determined by 2D-correlated Mn2+ hyperfine spectroscopy

The tetracycline-binding RNA aptamer (TC-aptamer) binds its cognate ligand the antibiotic tetracycline (TC) via a Mg2+ or Mn2+ ion with high affinity at high divalent metal ion concentrations (KD=800pM, ⩾10 mM). These concentrations lie above the physiological divalent metal ion concentration of ca....

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Bibliografiske detaljer
Main Authors:	Hetzke, T, Bowen, A, Vogel, M, Gauger, M, Suess, B, Prisner, T
Format:	Journal article
Sprog:	English
Udgivet:	Elsevier 2019

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