In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.

In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.

Rapid binding of peptides to MHC class II molecules is normally limited to a deep endosomal compartment where the coordinate action of low pH and HLA-DM displaces the invariant chain remnant CLIP or other peptides from the binding site. Exogenously added peptides are subject to proteolytic degradati...

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Những tác giả chính: Call, M, Xing, X, Cuny, G, Seth, N, Altmann, D, Fugger, L, Krogsgaard, M, Stein, R, Wucherpfennig, K
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2009

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