In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.

In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.

Rapid binding of peptides to MHC class II molecules is normally limited to a deep endosomal compartment where the coordinate action of low pH and HLA-DM displaces the invariant chain remnant CLIP or other peptides from the binding site. Exogenously added peptides are subject to proteolytic degradati...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Call, M, Xing, X, Cuny, G, Seth, N, Altmann, D, Fugger, L, Krogsgaard, M, Stein, R, Wucherpfennig, K
Materialtyp:	Journal article
Språk:	English
Publicerad:	2009

Liknande verk

Rapid peptide exchange on MHC class I by small molecules elucidates dynamics of bound peptide
av: Andries Hadeler, et al.
Publicerad: (2022-01-01)

Peptide Loading on MHC Class I Molecules of Tumor Cells
av: Loredana Cifaldi, et al.
Publicerad: (2016-09-01)

Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules.
av: Shashank Gupta, et al.
Publicerad: (2008-01-01)

TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst
av: Clemens Hermann, et al.
Publicerad: (2015-10-01)

Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules.
av: Dzhambazov, B, et al.
Publicerad: (2006)

Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection
av: Raghavendra Anjanappa, et al.
Publicerad: (2020-03-01)

Limitations of Ab initio predictions of peptide binding to MHC class II molecules.
av: Hao Zhang, et al.
Publicerad: (2010-02-01)

Phosphosite-dependent presentation of dual phosphorylated peptides by MHC class I molecules
av: Yingze Zhao, et al.
Publicerad: (2022-04-01)

Biophysical evidence for conformational change in MHC class I molecules upon peptide binding
av: Springer, S, et al.
Publicerad: (1997)

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding
av: Paul E Chappell, et al.
Publicerad: (2015-04-01)

Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithms
av: Feng Lin, et al.
Publicerad: (2007-11-01)

Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms.
av: Bikoff, E, et al.
Publicerad: (1998)

A method to quantify binding of unlabeled peptides to class I MHC molecules and detect their allele specificity.
av: Elvin, J, et al.
Publicerad: (1993)

Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer.
av: Spies, T, et al.
Publicerad: (1992)

Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
av: Koch, M, et al.
Publicerad: (2007)

A Mechanistic Model for Predicting Cell Surface Presentation of Competing Peptides by MHC Class I Molecules
av: Denise S. M. Boulanger, et al.
Publicerad: (2018-07-01)

Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach
av: Joly Etienne, et al.
Publicerad: (2001-06-01)

A community resource benchmarking predictions of peptide binding to MHC-I molecules.
av: Bjoern Peters, et al.
Publicerad: (2006-06-01)

Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules
av: Spencer, CT, et al.
Publicerad: (2015)

The Discovery of Small-Molecule Mimicking Peptides through Phage Display
av: Brendan P. Orner, et al.
Publicerad: (2011-01-01)

Formation of complexes between self-peptides and MHC class II molecules in cells defective for presentation of exogenous protein antigens.
av: Bikoff, E
Publicerad: (1992)

MHC II molecules in inflammatory diseases: interplay of qualities and quantities.
av: Friese, M, et al.
Publicerad: (2005)

Functions of nonclassical MHC and non-MHC-encoded class I molecules.
av: Braud, V, et al.
Publicerad: (1999)

Unlocking the secrets of the immunopeptidome: MHC molecules, ncRNA peptides, and vesicles in immune response
av: Arpita Balakrishnan, et al.
Publicerad: (2025-01-01)

Degenerate T-cell recognition of peptides on MHC molecules creates large holes in the T-cell repertoire.
av: Jorg J A Calis, et al.
Publicerad: (2012-01-01)

TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap
av: Andrew C. McShan, et al.
Publicerad: (2021-05-01)

MHC molecules lead many lives. Workshop on MHC Class I Molecules at the interface between Biology and Medicine.
av: Bowness, P, et al.
Publicerad: (2009)

Determination of class II peptide-MHC repertoires and recognition via large yeast-displayed libraries
av: Rappazzo, Charles Garrett.
Publicerad: (2020)

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes
av: Elien M. Doorduijn, et al.
Publicerad: (2018-01-01)

Yeast Display for the Identification of Peptide-MHC Ligands of Immune Receptors
av: Huisman, Brooke D, et al.
Publicerad: (2023)

Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
av: O'Callaghan, C, et al.
Publicerad: (1998)

Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules
av: Georgia F. Papadaki, et al.
Publicerad: (2023-01-01)

Assembly of MHC class I molecules analyzed in vitro.
av: Townsend, A, et al.
Publicerad: (1990)

MHC class II complexes sample intermediate states along the peptide exchange pathway
av: Marek Wieczorek, et al.
Publicerad: (2016-11-01)

Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding.
av: Springer, S, et al.
Publicerad: (1998)

A Peptide Filtering Relation Quantifies MHC Class I Peptide Optimization
av: Dalchau, N, et al.
Publicerad: (2011)

A peptide filtering relation quantifies MHC class I peptide optimization
av: Dalchau, N, et al.
Publicerad: (2011)

A peptide filtering relation quantifies MHC class I peptide optimization.
av: Dalchau, N, et al.
Publicerad: (2011)

A peptide filtering relation quantifies MHC class I peptide optimization.
av: Neil Dalchau, et al.
Publicerad: (2011-10-01)

Evidence of widespread binding of HLA class I molecules to peptides.
av: Frelinger, J, et al.
Publicerad: (1990)