A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure.
The mapping between biological genotypes and phenotypes is central to the study of biological evolution. Here, we introduce a rich, intuitive and biologically realistic genotype-phenotype (GP) map that serves as a model of self-assembling biological structures, such as protein complexes, and remains...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797091121789140992 |
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| author | Greenbury, S Johnston, I Louis, A Ahnert, SE |
| author_facet | Greenbury, S Johnston, I Louis, A Ahnert, SE |
| author_sort | Greenbury, S |
| collection | OXFORD |
| description | The mapping between biological genotypes and phenotypes is central to the study of biological evolution. Here, we introduce a rich, intuitive and biologically realistic genotype-phenotype (GP) map that serves as a model of self-assembling biological structures, such as protein complexes, and remains computationally and analytically tractable. Our GP map arises naturally from the self-assembly of polyomino structures on a two-dimensional lattice and exhibits a number of properties: redundancy (genotypes vastly outnumber phenotypes), phenotype bias (genotypic redundancy varies greatly between phenotypes), genotype component disconnectivity (phenotypes consist of disconnected mutational networks) and shape space covering (most phenotypes can be reached in a small number of mutations). We also show that the mutational robustness of phenotypes scales very roughly logarithmically with phenotype redundancy and is positively correlated with phenotypic evolvability. Although our GP map describes the assembly of disconnected objects, it shares many properties with other popular GP maps for connected units, such as models for RNA secondary structure or the hydrophobic-polar (HP) lattice model for protein tertiary structure. The remarkable fact that these important properties similarly emerge from such different models suggests the possibility that universal features underlie a much wider class of biologically realistic GP maps. |
| first_indexed | 2024-03-07T03:28:33Z |
| format | Journal article |
| id | oxford-uuid:b9e3cf4c-0936-4f4b-be11-6ca09650aa20 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:28:33Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:b9e3cf4c-0936-4f4b-be11-6ca09650aa202022-03-27T05:06:11ZA tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b9e3cf4c-0936-4f4b-be11-6ca09650aa20EnglishSymplectic Elements at Oxford2014Greenbury, SJohnston, ILouis, AAhnert, SEThe mapping between biological genotypes and phenotypes is central to the study of biological evolution. Here, we introduce a rich, intuitive and biologically realistic genotype-phenotype (GP) map that serves as a model of self-assembling biological structures, such as protein complexes, and remains computationally and analytically tractable. Our GP map arises naturally from the self-assembly of polyomino structures on a two-dimensional lattice and exhibits a number of properties: redundancy (genotypes vastly outnumber phenotypes), phenotype bias (genotypic redundancy varies greatly between phenotypes), genotype component disconnectivity (phenotypes consist of disconnected mutational networks) and shape space covering (most phenotypes can be reached in a small number of mutations). We also show that the mutational robustness of phenotypes scales very roughly logarithmically with phenotype redundancy and is positively correlated with phenotypic evolvability. Although our GP map describes the assembly of disconnected objects, it shares many properties with other popular GP maps for connected units, such as models for RNA secondary structure or the hydrophobic-polar (HP) lattice model for protein tertiary structure. The remarkable fact that these important properties similarly emerge from such different models suggests the possibility that universal features underlie a much wider class of biologically realistic GP maps. |
| spellingShingle | Greenbury, S Johnston, I Louis, A Ahnert, SE A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure. |
| title | A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure. |
| title_full | A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure. |
| title_fullStr | A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure. |
| title_full_unstemmed | A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure. |
| title_short | A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure. |
| title_sort | tractable genotype phenotype map modelling the self assembly of protein quaternary structure |
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